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TWEAK Polyclonal Antibody
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FIGURE: 1 / 3
TWEAK Antibody (PA5150065) in IHC (P)
Immunohistochemistry analysis of TWEAK in paraffin-embedded Human Cardiac Muscle tissue. Samples were incubated with TWEAK Polyclonal (Product # PA5150065) antibody using a dilution of 20 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG (2 µg/mL) and DAB.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5150065
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Rabbit
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Tumor Necrosis Factor Ligand Superfamily, Member 12 (TNFSF12) (Asp65-Gln247)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
TNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF) of structurally related cytokines. Like most other members of this family, TWEAK is a cell surface-associated type II transmembrane protein although a smaller, biologically active form can also be generated by cleavage near the cell membrane. TWEAK has multiple biological activities, including stimulation of cell growth and angiogenesis, induction of inflammatory cytokines, in addition to stimulation of apoptosis. The TWEAK signal transduction pathway has not been well established but it appears to signal via TweakR/Fn14 in a manner similar to that described for other TNFSF members that bind receptors lacking death domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: APO3 ligand; APO3/DR3 ligand; ligand in the TNF family; MGC129581; MGC20669; TNF homolog; TNF-related WEAK inducer of apoptosis; tumor necrosis factor (ligand) superfamily, member 12; tumor necrosis factor ligand 4A; tumor necrosis factor superfamily member 12; tumor necrosis factor-like weak inducer of apoptosis; unnamed protein product
Gene Aliases: APO3L; Dr3l; DR3LG; TNF12; TNLG4A; TWEAK
UniProt ID: (Human) O43508, (Mouse) O54907
Entrez Gene ID: (Pig) 100127163, (Human) 8742, (Rat) 360548, (Mouse) 21944
apoptotic process
immune response
signal transduction
positive regulation of protein catabolic process
extrinsic apoptotic signaling pathway
positive regulation of extrinsic apoptotic signaling pathway
positive regulation of endothelial cell proliferation
endothelial cell migration
positive regulation of angiogenesis
apoptotic signaling pathway
Disclaimer
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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