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Invitrogen
PHD2 Polyclonal Antibody
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PHD2 Antibody (PA5-17050) in WB
Western blot was performed using Anti-PHD2 Polyclonal Antibody (Product # PA5-17050) and a 47-50kDa band corresponding to Egl nine homolog 1 was observed across all the cell lines and tissue models tested. Whole-cell extracts (30 µg lysate) of A549 (Lane 1), U-87 MG (Lane 2), U-2 OS (Lane 3), MDA-MB-231 (Lane 4), HeLa (Lane 5), HeLa treated with cobalt chloride (200 micromolar for 48h) (Lane 6), Hep G2 (Lane 7), Mouse Heart (Lane 8), Mouse Brain (Lane 9) were electrophoresed using NuPAGE™ 10% Bis-Tris Protein Gel (Product # NP0302BOX). Res... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-17050
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues surrounding Val226 of human PHD-2/Egln1 protein
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
77 µg/mL
规格
7.7 µg
纯化类型
Antigen affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
It is not recommended to aliquot this antibody.
靶标信息
SYMPK is a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types.This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: C1ORF12 antibody; Egl nine homolog 1; EGLN 1 EGLN1; HIF PH2; HIF-P4H 2; HIF-PH2; HIF-prolyl hydroxylase 2; Hypoxia-inducible factor prolyl hydroxylase 2; P4H2; PHD2; Prolyl Hy; Prolyl hydroxylase domain-containing protein 2; SM-20
基因别名: AI503754; C1orf12; EGLN1; Hif-p4h-2; HIF-PH2; HPH-2; ORF13; Phd2; PNAS-118; PNAS-137; SM-20
UniProt ID: (Mouse) Q91YE3
Entrez Gene ID: (Mouse) 112405
iron ion binding
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
enzyme binding
L-ascorbic acid binding
peptidyl-proline dioxygenase activity
peptidyl-proline 4-dioxygenase activity
metal ion binding
dioxygenase activity
response to hypoxia
peptidyl-proline hydroxylation to 4-hydroxy-L-proline
negative regulation of cAMP catabolic process
oxygen homeostasis
negative regulation of sequence-specific DNA binding transcription factor activity
regulation of angiogenesis
negative regulation of cyclic-nucleotide phosphodiesterase activity
cardiac muscle tissue morphogenesis
oxidation-reduction process
heart trabecula formation
ventricular septum morphogenesis
labyrinthine layer development
response to nitric oxide
Disclaimer
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