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Invitrogen

14-3-3 epsilon Polyclonal Antibody

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1 Published Figure
1 Reference
View all (21) 14-3-3 epsilon antibodies

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Product Details

PA5-17104

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
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Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to the sequence of human 14-3-3 e

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

34 µg/mL

Amount

3.4 µg

Purification

Antigen affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10982751

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

14-3-3 epsilon belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 14-3-3 epsilon; 14-3-3 protein epsilon; 14-3-3E; epididymis luminal protein 2; mitochondrial import stimulation factor (MSF) L subunit; Mitochondrial import stimulation factor L subunit; MSF L; protein kinase C inhibitor protein-1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein epsilon polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein, epsilon polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide; unnamed protein product

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Gene Aliases: 14-3-3E; AU019196; HEL2; KCIP-1; MDCR; MDS; YWHAE

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UniProt ID: (Human) P62258, (Rat) P62260, (Mouse) P62259

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Entrez Gene ID: (Human) 7531, (Rat) 29753, (Mouse) 22627

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Function(s)
RNA binding protein phosphatase inhibitor activity calcium channel regulator activity protein binding potassium channel regulator activity calcium channel inhibitor activity enzyme binding protein phosphatase binding protein domain specific binding MHC class II protein complex binding ubiquitin protein ligase binding signaling adaptor activity identical protein binding histone deacetylase binding ion channel binding cadherin binding protein heterodimerization activity phosphoserine binding phosphoprotein binding scaffold protein binding protein sequestering activity molecular function inhibitor activity protein kinase C inhibitor activity protein complex binding poly(A) RNA binding scaffold/adaptor protein transporter
Process(es)
MAPK cascade neuron migration cytoplasmic pattern recognition receptor signaling pathway regulation of heart rate by hormone protein targeting ER to Golgi vesicle-mediated transport Golgi to plasma membrane transport signal transduction regulation of mitotic cell cycle protein localization substantia nigra development hippocampus development cerebral cortex development cellular potassium ion homeostasis negative regulation of toll-like receptor signaling pathway positive regulation of toll-like receptor signaling pathway toll-like receptor 4 signaling pathway protein localization to nucleus cellular response to heat hippo signaling positive regulation of hippo signaling intracellular signal transduction proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of protein export from nucleus regulation of cytosolic calcium ion concentration regulation of membrane repolarization protein localization to endoplasmic reticulum protein K11-linked ubiquitination membrane repolarization during cardiac muscle cell action potential regulation of heart rate by cardiac conduction regulation of potassium ion transmembrane transport negative regulation of calcium ion export across plasma membrane negative regulation of protein dephosphorylation negative regulation of protein serine/threonine kinase activity regulation of potassium ion transmembrane transporter activity negative regulation of peptidyl-serine dephosphorylation
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