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Invitrogen
Shootin1 Polyclonal Antibody
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Product Details
PA5-17167
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide surrounding Lys450 of human shootin1
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
30 µg/mL
Amount
3 µg
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
SHTN1 is a protein coding gene involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Shootin-1; Shootin1; shot1; unnamed protein product
Gene Aliases: KIAA1598; mKIAA1598; shootin-1; Shootin1; SHTN1
UniProt ID: (Mouse) Q8K2Q9, (Rat) A0MZ67, (Human) A0MZ66
Entrez Gene ID: (Mouse) 71653, (Rat) 292139, (Human) 57698
axonogenesis
neuron projection morphogenesis
regulation of establishment of cell polarity
regulation of neuron migration
multicellular organism development
membrane depolarization
substrate-dependent cell migration, cell extension
Ras protein signal transduction
Cdc42 protein signal transduction
netrin-activated signaling pathway
positive regulation of axon extension
cytoplasmic actin-based contraction involved in cell motility
endoplasmic reticulum polarization
actin filament bundle retrograde transport
positive regulation of neuron migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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