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Invitrogen
SOCS2 Polyclonal Antibody
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图: 1 / 5
SOCS2 Antibody (PA5-17219) in WB
Western blot was performed using Anti-SOCS2 Polyclonal Antibody (Product # PA5-17219) and a 22kDa band corresponding to SOCS2 was observed across cell lines tested except U-2 OS and Jurkat which are reported to be negative for SOCS2 expression. Whole cell extracts (30 µg lysate) of K-562 (Lane 1), Caco-2 (Lane 2), PC-3 (Lane 3), HCT 116 (Lane 4), U-2 OS (Lane 5) and Jurkat (Lane 6) were electrophoresed using Novex® NuPAGE® 4-12 % Bis-Tris gel (Product # NP0322BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Pro... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-17219
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues at the carboxyl terminus of human SOCS2
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
374 µg/mL
规格
37.4 µg
纯化类型
Antigen affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
It is not recommended to aliquot this antibody.
靶标信息
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon (IFN)-gamma. The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CIS-2; cytokine inducible SH2-containing protein 2; Cytokine-inducible SH2 protein 2; SOCS-2; SSI-2; STAT-induced STAT inhibitor 2; Suppressor of cytokine signaling 2
基因别名: 8030460M17; AI527257; AW108012; CIS2; Cish2; D130043N08Rik; hg; JAB; SOCS-2; SOCS2; SSI-2; SSI2; STATI2
UniProt ID: (Mouse) O35717, (Rat) O88582
Entrez Gene ID: (Mouse) 216233, (Rat) 84607
regulation of cell growth
negative regulation of protein kinase activity
lactation
negative regulation of signal transduction
cytokine-mediated signaling pathway
response to estradiol
cellular response to hormone stimulus
intracellular signal transduction
regulation of growth
regulation of multicellular organism growth
negative regulation of multicellular organism growth
positive regulation of neuron differentiation
negative regulation of JAK-STAT cascade
negative regulation of insulin receptor signaling pathway
growth hormone receptor signaling pathway
mammary gland alveolus development
aging
protein ubiquitination
response to peptide hormone
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