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Invitrogen
Phospho-PAR4 (Thr163) Polyclonal Antibody
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FIGURE: 1 / 2
Phospho-PAR4 (Thr163) Antibody (PA5-17343) in WB
Western blot analysis of Phospho-PAR-4 pThr163 in extracts from HeLa cells, untreated or treated with a phosphatase inhibitor (100 nM, 5 minutes), using Phospho-PAR-4 pThr163 polyclonal antibody (Product # PA5-17343) (upper) or a PAR-4 polyclonal antibody (lower).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-17343
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues surrounding Thr163 of human PAR-4 (Thr155 in rat and Thr156 in mouse)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
190 µg/mL
Amount
19 µg
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: induced in androgen-independent prostate cells by effectors of apoptosis; par-4 induced by effectors of apoptosis; PAR-4/p33; PAR-4/p38; PAWR; PRKC, apoptosis, WT1, regulator; pro-apoptotic protein; prostate apoptosis response 4; prostate apoptosis response 4 protein; Prostate apoptosis response protein 4; prostate apoptosis response protein PAR-4; prostate apoptosis response-4; transcriptional repressor Par-4-like protein PAWR; transcriptional repressor PAR4; unnamed protein product; WT1-interacting protein
Gene Aliases: 2310001G03Rik; Par-4; PAR4
UniProt ID: (Human) Q96IZ0, (Rat) Q62627, (Mouse) Q925B0
Entrez Gene ID: (Human) 5074, (Rat) 64513, (Mouse) 114774
negative regulation of transcription from RNA polymerase II promoter
apoptotic process
response to iron(II) ion
positive regulation of gene expression
negative regulation of gene expression
negative regulation of B cell proliferation
response to estradiol
response to lipopolysaccharide
negative regulation of T cell proliferation
positive regulation of amyloid precursor protein biosynthetic process
positive regulation of apoptotic process
positive regulation of neuron apoptotic process
positive regulation of action potential
negative regulation of fibroblast proliferation
negative regulation of T cell receptor signaling pathway
detection of temperature stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
actin filament bundle assembly
positive regulation of hindgut contraction
cellular response to vitamin E
cellular response to interleukin-1
cellular response to follicle-stimulating hormone stimulus
cellular response to estradiol stimulus
negative regulation of calcium ion import
apoptotic signaling pathway
calcium ion import across plasma membrane
positive regulation of relaxation of smooth muscle
positive regulation of hydrogen peroxide-mediated programmed cell death
positive regulation of leukocyte tethering or rolling
positive regulation of neuronal action potential
positive regulation of neutrophil extravasation
positive regulation of cellular senescence
positive regulation of intrinsic apoptotic signaling pathway
negative regulation of epithelial to mesenchymal transition
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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