Search
Invitrogen
Phospho-AMPK alpha-1,2 (Ser485, Ser491) Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
图: 1 / 1
Phospho-AMPK alpha-1,2 (Ser485, Ser491) Antibody (PA5-17543) in WB
Western blot analysis of Phospho-AMPK-alpha1 pSer485/AMPK-alpha2 pSer491 in extracts from HEK293 cells, lambda phosphatase-treated or oligomycin-treated, using Phospho-AMPK-alpha1 pSer485/AMPK-alpha2 pSer491 polyclonal antibody (Product # PA5-17543) (upper) or an AMPK-alpha antibody (lower).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-17543
产品规格
种属反应
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phosphopeptide corresponding to residues surrounding pSer491 of human AMPKa2
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
4 µg/mL
规格
0.4 µg
纯化类型
Antigen affinity chromatography, Protein A
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with other related proteins.
靶标信息
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: 5'-AMP-activated protein kinase catalytic subunit alpha-1; 5'-AMP-activated protein kinase catalytic subunit alpha-2; AAPK2; ACACA kinase; Acetyl-CoA carboxylase kinase; AMP-activated protein kinase; AMP-activated protein kinase alpha-2 variant B; AMP-activated protein kinase, alpha 1 catalytic subunit; AMPK alpha-1 chain; AMPK alpha-2 chain; AMPK subunit alpha-1; AMPK subunit alpha-2; AMPK-alpha-1 chain; HMGCR kinase; Hydroxymethylglutaryl-CoA reductase kinase; pAMPK; prkaa2; Tau-protein kinase PRKAA1
基因别名: 2310008I11Rik; A830082D05; AI194361; AI450832; AL024255; AMPK; AMPK1; AMPK2; Ampka2; AMPKalpha1; AMPKalpha2; C130083N04Rik; PRKAA1; PRKAA2
UniProt ID: (Rat) P54645, (Mouse) Q5EG47, (Rat) Q09137, (Mouse) Q8BRK8
Entrez Gene ID: (Rat) 65248, (Mouse) 105787, (Rat) 78975, (Mouse) 108079
chromatin binding
protein kinase activity
protein serine/threonine kinase activity
AMP-activated protein kinase activity
protein binding
ATP binding
protein C-terminus binding
kinase binding
histone serine kinase activity
eukaryotic elongation factor-2 kinase activator activity
metal ion binding
[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
tau-protein kinase activity
[acetyl-CoA carboxylase] kinase activity
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein serine/threonine/tyrosine kinase activity
protein binding, bridging
non-receptor serine/threonine protein kinase
activation of MAPK activity
glucose metabolic process
transcription, DNA-templated
regulation of transcription, DNA-templated
protein phosphorylation
fatty acid biosynthetic process
cholesterol biosynthetic process
autophagy
positive regulation of cell proliferation
lipid biosynthetic process
response to UV
cold acclimation
response to gamma radiation
positive regulation of autophagy
positive regulation of gene expression
response to activity
Wnt signaling pathway
negative regulation of translation
fatty acid oxidation
response to caffeine
cellular response to nutrient levels
negative regulation of TOR signaling
histone-serine phosphorylation
cellular response to glucose starvation
response to hydrogen peroxide
glucose homeostasis
regulation of circadian rhythm
negative regulation of apoptotic process
positive regulation of gluconeogenesis
positive regulation of glycolytic process
positive regulation of fatty acid oxidation
positive regulation of glucose import
rhythmic process
negative regulation of lipid catabolic process
protein heterooligomerization
fatty acid homeostasis
regulation of vesicle-mediated transport
cellular response to hydrogen peroxide
cellular response to ethanol
cellular response to prostaglandin E stimulus
cellular response to organonitrogen compound
cellular response to hypoxia
response to camptothecin
regulation of energy homeostasis
negative regulation of glucose import in response to insulin stimulus
lipid metabolic process
fatty acid metabolic process
steroid biosynthetic process
steroid metabolic process
cholesterol metabolic process
sterol biosynthetic process
phosphorylation
chromatin modification
regulation of peptidyl-serine phosphorylation
intracellular signal transduction
positive regulation of skeletal muscle tissue development
regulation of lipid metabolic process
response to stress
regulation of gene expression
response to muscle activity
regulation of macroautophagy
cellular response to drug
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
