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Invitrogen
MRE11 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-17573
产品规格
种属反应
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues surrounding Lys496 of human Mre11A
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
163 µg/mL
规格
16.3 µg
纯化类型
Antigen affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
It is not recommended to aliquot this antibody.
靶标信息
MRE11 (double-strand break repair protein MRE11) is a component of the MRN complex. This complex plays a central role in double-strand break repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-stranded endonuclease activity and double-strand-specific 3'-5' exonuclease activity which are provided by MRE11. RAD50 is required to bind DNA ends and hold them in close proximity. Mutations in the gene could result in ataxia-telangiectasia-like disorder 1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Double-strand break repair protein MRE11; Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; Meiotic recombination 11 homolog A; mmMRE11A; MRE11 homolog 1; MRE11 homolog A
基因别名: HNGS1; MRE11; MRE11A; Mre11b
UniProt ID: (Rat) Q9JIM0, (Mouse) Q61216
Entrez Gene ID: (Rat) 64046, (Mouse) 17535
DNA binding
ATP-dependent DNA helicase activity
endonuclease activity
exonuclease activity
protein binding
protein C-terminus binding
3'-5' exonuclease activity
manganese ion binding
single-stranded DNA endodeoxyribonuclease activity
nuclease activity
endodeoxyribonuclease activity
hydrolase activity
telomere maintenance
base-excision repair
nucleotide-excision repair
double-strand break repair
cellular response to DNA damage stimulus
sister chromatid cohesion
mitotic G2 DNA damage checkpoint
synapsis
heart development
cell proliferation
intra-S DNA damage checkpoint
positive regulation of protein autophosphorylation
DNA duplex unwinding
negative regulation of DNA endoreduplication
positive regulation of kinase activity
negative regulation of viral entry into host cell
chromosome organization
meiotic cell cycle
nucleic acid phosphodiester bond hydrolysis
DNA metabolic process
DNA repair
double-strand break repair via nonhomologous end joining
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
