Search
Invitrogen
Phospho-IKK alpha/beta (Ser176, Ser180) Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-17593
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Phosphopeptide corresponding to a region surrounding pSer177/181 of IKKβ
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
13.8 µg/mL
Amount
1.38 µg
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
IKK alpha/beta is encoded by CHUK (conserved helix-loop-helix ubiquitous kinase) and IKKB (inhibitor of kappa light polypeptide gene enhancer in B-cells) gene located in chromosome 10 and 8 respectively in humans. Upon stimulation by agents that activate the NF-kB pathway such as TNF alpha, the two subunits of IKK complex, IKK alpha and IKK -beta alongside a regulator NEMO (IKK gamma) phosphorylates IkB proteins. This targets the later for ubiquitin mediated degradation and phosphorylation of NF-kB leading to subsequent translocation to the nucleus. Phosphorylation at serine 176 and 180 located in the activation loop causes a confirmation change that is required for the activation of the kinases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Conserved helix-loop-helix ubiquitous kinase; EC 2.7.11.10; I kappa B kinase 1; I-kappa-B kinase 1; I-kappa-B kinase 2; I-kappa-B kinase alpha; I-kappa-B-kinase beta; IkappaB kinase; IkappaB kinase alpha; IKK alpha; IKK-1; IKK-2; IKK-A; IKK-B; IKK-beta; IKK2; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of kappaB kinase beta; inhibitor of nuclear factor kappa B kinase beta subunit; Inhibitor of nuclear factor kappa-B kinase subunit alpha; Inhibitor of nuclear factor kappa-B kinase subunit beta; NFKBIKA; NFKBIKB; Nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NF-kappa-B inhibitor kinase beta; Serine/threonine protein kinase IKBKB; TCF-16; TCF17; Transcription factor 16
Gene Aliases: AI132552; AI256658; AIM-1; CHUK; Chuk1; Fbx24; Fbxo24; IKBKA; IKBKB; IKK-2; IKK-beta; IKK1; IKK2; IKK[b]; IKKA; IKKB; IKKbeta; NFKBIKA; TCF16
UniProt ID: (Mouse) O88351, (Rat) Q9QY78
Entrez Gene ID: (Mouse) 12675, (Rat) 309361, (Mouse) 16150, (Rat) 84351
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
protein binding
ATP binding
IkappaB kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein homodimerization activity
protein heterodimerization activity
scaffold protein binding
protein kinase binding
non-receptor serine/threonine protein kinase
protein modifying enzyme
morphogenesis of an epithelial sheet
protein phosphorylation
I-kappaB phosphorylation
Rho protein signal transduction
lactation
response to organic substance
phosphorylation
signal transduction by protein phosphorylation
osteoclast differentiation
response to lipopolysaccharide
mammary gland epithelial cell proliferation
response to muscle stretch
odontogenesis of dentin-containing tooth
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of transcription from RNA polymerase II promoter
striated muscle cell differentiation
mammary gland alveolus development
cellular response to tumor necrosis factor
skeletal muscle contraction
response to toxic substance
response to acetate
response to hydroperoxide
response to drug
response to amino acid
B cell homeostasis
positive regulation of cell proliferation
positive regulation of sodium ion transport
neuron projection development
serine phosphorylation of STAT protein
positive regulation of NF-kappaB transcription factor activity
positive regulation of neuron death
positive regulation of cation channel activity
response to fatty acid
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support