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Invitrogen
GRB2 Polyclonal Antibody
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图: 1 / 7
GRB2 Antibody (PA5-17692) in ICC/IF
Immunofluorescence analysis of GRB2 was performed using 70% confluent log phase A-431 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with GRB2 Rabbit Polyclonal Antibody(Product # PA5-17692) at 1:100 dilution in 0.1% BSA, incubated at 4 degree Celsius overnight and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-17692
产品规格
种属反应
Bovine,
Hamster,
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to carboxy-terminal residues of human GRB2
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
217 µg/mL
规格
21.7 µg
纯化类型
Antigen affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
It is not recommended to aliquot this antibody.
靶标信息
GRB 2 protein contains one SH2 domain flanked on both sides by an SH3 domain. In response to EGF, GRB 2 binds, through its SH3 domains, to the guanine nucleotide exchange factor, Sos. The GRB 2-Sos complex then binds the EGF receptor. These interactions play a critical role in the activation of the p21 ras signaling pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Adapter protein GRB2; ASH protein; Growth factor receptor-bound protein 2; OTTHUMP00000166097; OTTHUMP00000166098; Protein Ash; SH2/SH3 adapter GRB2
基因别名: AA408164; ASH; GRB2
UniProt ID: (Mouse) Q60631, (Rat) P62994
Entrez Gene ID: (Bovine) 535298, (Chinese hamster) 100769627, (Mouse) 14784, (Rat) 81504
phosphotyrosine binding
SH3/SH2 adaptor activity
epidermal growth factor receptor binding
neurotrophin TRKA receptor binding
protein binding
SH3 domain binding
protein kinase binding
protein phosphatase binding
protein domain specific binding
identical protein binding
insulin receptor substrate binding
poly(A) RNA binding
ephrin receptor binding
phosphoprotein binding
Ras protein signal transduction
aging
insulin receptor signaling pathway
fibroblast growth factor receptor signaling pathway
positive regulation of signal transduction
cell differentiation
positive regulation of actin filament polymerization
receptor internalization
signal transduction in response to DNA damage
regulation of MAPK cascade
anatomical structure formation involved in morphogenesis
protein heterooligomerization
branching involved in labyrinthine layer morphogenesis
cellular response to ionizing radiation
positive regulation of reactive oxygen species metabolic process
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