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Invitrogen
GNAQ Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-17693
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues of human guanine nucleotide-binding protein Ga (q) subunit
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
180 µg/mL
Amount
18 µg
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Guanine nucleotide-binding proteins are a family of heterotrimeric proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GTP for GDP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. The G protein alpha and beta-gamma subunits are capable of regulating various cellular effectors. Activation is terminated by a GTPase intrinsic to the G-alpha subunit. G-alpha-q is the alpha subunit of one of the heterotrimeric GTP-binding proteins that mediates stimulation of phospholipase C-beta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G alpha q; guanine nucleotide binding protein (G protein), q polypeptide; guanine nucleotide binding protein alpha q subunit; guanine nucleotide binding protein, alpha q polypeptide; guanine nucleotide regulatory protein G alpha q; Guanine nucleotide-binding protein alpha-q; Guanine nucleotide-binding protein G(q) subunit alpha; heterotrimeric guanine nucleotide-binding protein alpha q subunit
Gene Aliases: 1110005L02Rik; 6230401I02Rik; AA408290; AW060788; Dsk1; Dsk10; Galphaq; GAQ; GNAQ; Gq; GqI
UniProt ID: (Rat) P82471, (Mouse) P21279
Entrez Gene ID: (Bovine) 536654, (Rat) 81666, (Mouse) 14682
G-protein coupled receptor binding
GTPase activity
signal transducer activity
GTPase activator activity
protein binding
GTP binding
G-protein beta/gamma-subunit complex binding
type 2A serotonin receptor binding
protein complex binding
metal ion binding
nucleotide binding
guanyl nucleotide binding
heterotrimeric G-protein
skeletal system development
action potential
negative regulation of protein kinase activity
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
activation of phospholipase C activity
glutamate receptor signaling pathway
heart development
metabolic process
post-embryonic development
neuron remodeling
forebrain neuron development
regulation of catenin import into nucleus
maternal behavior
embryonic digit morphogenesis
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of potassium ion transport
positive regulation of GTPase activity
regulation of melanocyte differentiation
developmental pigmentation
positive regulation of smooth muscle cell proliferation
protein stabilization
phospholipase C-activating dopamine receptor signaling pathway
signal transduction
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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