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Phospho-EGFR/ErbB2 (Tyr1173, Tyr1248) Polyclonal Antibody

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Phospho-EGFR/ErbB2 (Tyr1173, Tyr1248) Polyclonal Antibody

产品信息

PA5-17844

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic phosphopeptide corresponding to residues surrounding pTyr1248 of human ErbB2
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

纯化类型

Antigen affinity chromatography

保存液

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

内含物

no preservative

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_11001612

产品详细信息

It is not recommended to aliquot this antibody.

靶标信息

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: approximately 68 kDa secreted autoinhibitor glycoprotein; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; c-erb B2/neu protein; CD340; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; contains extracellular domain; EGFR vIII; Epidermal growth factor receptor; epidermal growth factor receptor tyrosine kinase domain; erb-b2 receptor tyrosine kinase 1; GIG40; HER2 receptor; HER2/neu receptor; herstatin; human epidermal growth factor receptor 2; membrane protein; Metastatic lymph node gene 19 protein; MLN 19; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; Oncogene ERBB; p185erbB2; PIG61; Proto-oncogene c-ErbB-1; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-1; Receptor tyrosine-protein kinase erbB-2; Tyrosine kinase-type cell surface receptor HER2; unnamed protein product; Urogastrone; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog; wa2; Wa5

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基因别名: c-ERB-2; c-ERB2; CD340; EGFR; ERBB; ERBB1; ERBB2; ERRP; HER-2; HER-2/neu; HER1; HER2; mENA; MLN 19; MLN-19; MLN19; NEU; NGL; NISBD2; NNCIS; p185(erbB2); PIG61; TKR1; VSCN2

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UniProt ID: (Human) P00533, (Human) P04626

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Entrez Gene ID: (Human) 1956, (Human) 2064

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功能
nucleotide binding virus receptor activity chromatin binding double-stranded DNA binding protein kinase activity MAP kinase kinase kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane signaling receptor activity epidermal growth factor-activated receptor activity protein binding ATP binding kinase activity transferase activity enzyme binding kinase binding protein phosphatase binding protein tyrosine kinase activator activity ubiquitin protein ligase binding identical protein binding cadherin binding epidermal growth factor binding actin filament binding ATPase binding RNA polymerase I core binding receptor binding coreceptor activity growth factor binding receptor tyrosine kinase binding ErbB-3 class receptor binding protein heterodimerization activity
参与通路
protein phosphorylation signal transduction cell surface receptor signaling pathway enzyme linked receptor protein signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway epidermal growth factor receptor signaling pathway nervous system development peripheral nervous system development heart development neuromuscular junction development motor neuron axon guidance cell proliferation positive regulation of gene expression Schwann cell development peptidyl-tyrosine phosphorylation neuron differentiation positive regulation of cell growth regulation of microtubule-based process immature T cell proliferation in thymus negative regulation of immature T cell proliferation in thymus positive regulation of Rho protein signal transduction intracellular signal transduction ERBB2 signaling pathway ERBB2-ERBB3 signaling pathway ERBB2-EGFR signaling pathway ERBB2-ERBB4 signaling pathway wound healing regulation of cell proliferation myelination negative regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of MAPK cascade protein kinase B signaling positive regulation of translation regulation of angiogenesis positive regulation of cell adhesion positive regulation of transcription from RNA polymerase I promoter oligodendrocyte differentiation positive regulation of epithelial cell proliferation regulation of ERK1 and ERK2 cascade cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus semaphorin-plexin signaling pathway positive regulation of protein targeting to membrane neurotransmitter receptor localization to postsynaptic specialization membrane positive regulation of intracellular signal transduction MAPK cascade cell morphogenesis ossification embryonic placenta development positive regulation of protein phosphorylation hair follicle development salivary gland morphogenesis learning or memory positive regulation of cell proliferation epidermis development cerebral cortex cell migration positive regulation of cell migration positive regulation of peptidyl-serine phosphorylation negative regulation of epidermal growth factor receptor signaling pathway negative regulation of protein catabolic process positive regulation of phosphorylation positive regulation of DNA repair positive regulation of DNA replication positive regulation of transcription from RNA polymerase II promoter viral entry into host cell positive regulation of fibroblast proliferation digestive tract morphogenesis epithelial cell proliferation regulation of peptidyl-tyrosine phosphorylation protein insertion into membrane positive regulation of protein kinase B signaling morphogenesis of an epithelial fold eyelid development in camera-type eye response to UV-A positive regulation of ERK1 and ERK2 cascade cellular response to amino acid stimulus cellular response to estradiol stimulus positive regulation of protein kinase C signaling positive regulation of canonical Wnt signaling pathway cell-cell adhesion positive regulation of G1/S transition of mitotic cell cycle positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of protein localization to plasma membrane negative regulation of cardiocyte differentiation
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