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Invitrogen
Phospho-EGFR/ErbB2 (Tyr1173, Tyr1248) Polyclonal Antibody
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Product Details
PA5-17844
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding pTyr1248 of human ErbB2
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD340; Epidermal growth factor receptor; Metastatic lymph node gene 19 protein; MLN 19; Oncogene ERBB; p185erbB2; Proto-oncogene c-ErbB-1; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-1; Receptor tyrosine-protein kinase erbB-2; Tyrosine kinase-type cell surface receptor HER2; Urogastrone; wa2; Wa5
Gene Aliases: EGFR; ERBB; ERBB1; ERBB2; HER1; HER2; MLN19; NEU; NGL
Entrez Gene ID: (Human) 1956, (Human) 2064
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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