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          • Primary Antibodies ›
          • PKC alpha/beta-2 Antibodies

          Invitrogen

          Phospho-PKC alpha/beta-2 (Thr638, Thr641) Polyclonal Antibody

          View all (3) PKC alpha/beta-2 antibodies

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          Cite Phospho-PKC alpha/beta-2 (Thr638, Thr641) Polyclonal Antibody

          Additional Information:
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          Product Details

          PA5-17904

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:1,000
          -

          Immunoprecipitation (IP)

          1:100
          -
          Product Specifications

          Species Reactivity

          Hamster, Human, Mouse, Non-human primate, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Synthetic phosphopeptide corresponding to residues surrounding pThr638 of human PKC alpha

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Purification

          Antigen affinity chromatography

          Storage buffer

          0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

          Contains

          no preservative

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_10989347

          Product Specific Information

          It is not recommended to aliquot this antibody.

          Target Information

          Protein Kinase c alpha (PKC alpha) is an 77 kDa member of the conventional group (cPKCs: sensitive to calcium, diacylglycerol, phosphatidylserine and phorbol esters) of the PKC family of serine/ threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC alpha is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of a broad range of cellular functions including proliferation, differentiation, development, migration, cell cell adhesion, cell extracellular matrix adhesion, and solute transport. The activation loop threonine (threonine 497 in PKC alpha) of conventional PKCs is phosphorylated by phosphoinositide dependent kinase 1 (PDK1). This phosphorylation is necessary for the autophosphorylation of threonine 638 in the carboxy terminus of PKC alpha, a step that is critical for regulating the rate of PKC alpha dephosphorylation and inactivation.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: AAG6; aging-associated gene 6; PKC-A; PKC-alpha; PKC-B; PKC-beta; PRKC Pan; Protein kinase C alpha type; protein kinase C alpha-polypeptide; protein kinase C beta I; protein kinase C beta II; Protein kinase C beta type; protein kinase C beta-II; protein kinase C, beta 1; protein kinase C, beta 1 polypeptide; protein kinase c-alpha; unnamed protein product

          View more View less

          Gene Aliases: A130082F03Rik; AAG6; AI875142; PKC-alpha; PKC-Beta; PKCA; PKCalpha; PKCB; PKCbeta; PKCI(2); PKCI+/-; PRKACA; PRKCA; PRKCB; PRKCB1; PRKCB2

          View more View less

          UniProt ID: (Human) P17252, (Human) P05771, (Mouse) P20444, (Rat) P05696, (Mouse) F2Z441, (Rat) P68403

          View more View less

          Entrez Gene ID: (Human) 5578, (Human) 5579, (Mouse) 18750, (Rat) 24680, (Mouse) 18751, (Rat) 25023

          View more View less

          Function(s)
          nucleotide binding protein kinase activity protein serine/threonine kinase activity protein kinase C activity calcium-dependent protein kinase C activity receptor binding integrin binding protein binding ATP binding zinc ion binding kinase activity transferase activity enzyme binding diacylglycerol binding histone kinase activity (H3-T6 specific) metal ion binding protein serine kinase activity chromatin binding transcription coactivator activity protein kinase C binding calcium channel regulator activity histone binding androgen receptor binding transferase activity, transferring phosphorus-containing groups ligand-dependent nuclear receptor transcription coactivator activity non-receptor serine/threonine protein kinase protein modifying enzyme
          Process(es)
          response to reactive oxygen species angiogenesis positive regulation of endothelial cell proliferation desmosome assembly chromatin remodeling protein phosphorylation apoptotic process mitotic nuclear envelope disassembly cell adhesion learning or memory response to mechanical stimulus response to toxic substance positive regulation of signal transduction positive regulation of endothelial cell migration positive regulation of cardiac muscle hypertrophy negative regulation of translation central nervous system neuron axonogenesis signal transduction involved in regulation of gene expression positive regulation of cell migration positive regulation of lipopolysaccharide-mediated signaling pathway positive regulation of insulin secretion response to estradiol negative regulation of glial cell apoptotic process intracellular signal transduction proteasome-mediated ubiquitin-dependent protein catabolic process response to peptide hormone regulation of mRNA stability protein kinase B signaling positive regulation of blood vessel endothelial cell migration response to ethanol positive regulation of macrophage differentiation positive regulation of angiogenesis positive regulation of bone resorption positive regulation of cell adhesion positive regulation of exocytosis positive regulation of mitotic cell cycle positive regulation of smooth muscle cell proliferation regulation of transport response to corticosterone positive regulation of protein kinase B signaling positive regulation of synapse assembly renal sodium ion absorption positive regulation of ERK1 and ERK2 cascade protein kinase C signaling response to interleukin-1 regulation of platelet aggregation apoptotic signaling pathway positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway positive regulation of angiotensin-activated signaling pathway negative regulation of cytokine production involved in inflammatory response positive regulation of cytokine production involved in inflammatory response response to phorbol 13-acetate 12-myristate positive regulation of dense core granule biogenesis adaptive immune response immune system process chromatin organization regulation of transcription from RNA polymerase II promoter calcium ion transport cellular calcium ion homeostasis signal transduction phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway regulation of glucose transport negative regulation of glucose transport positive regulation of vascular endothelial growth factor receptor signaling pathway B cell activation lipoprotein transport positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of transcription, DNA-templated negative regulation of insulin receptor signaling pathway B cell receptor signaling pathway cellular response to carbohydrate stimulus presynaptic modulation of chemical synaptic transmission regulation of synaptic vesicle exocytosis inactivation of MAPK activity negative regulation of protein phosphorylation positive regulation of protein phosphorylation regulation of the force of heart contraction chondrocyte differentiation negative regulation of protein kinase activity regulation of muscle contraction negative regulation of cell proliferation phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation neutrophil chemotaxis histone H3-T6 phosphorylation peptidyl-serine autophosphorylation negative regulation of heart contraction negative regulation of glucose import protein autophosphorylation regulation of receptor-mediated endocytosis positive regulation of inflammatory response regulation of peptidyl-tyrosine phosphorylation induction of positive chemotaxis intrinsic apoptotic signaling pathway aging response to organic cyclic compound establishment of protein localization response to antibiotic response to hypoxia transcription, DNA-templated regulation of transcription, DNA-templated regulation of dopamine secretion chromatin modification regulation of growth response to drug positive regulation of B cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity response to glucose dibenzo-p-dioxin metabolic process response to vitamin D positive regulation of odontogenesis of dentin-containing tooth
          It has to be done as per old AB suggested Products section.

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