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Invitrogen

PP2A alpha/beta Polyclonal Antibody

View all (10) PP2A alpha/beta antibodies

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PP2A alpha/beta Polyclonal Antibody

Product Details

PA5-17980

Applications
Tested Dilution
Publications

Western Blot (WB)

1-3 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

10 µg/mL
-

Immunocytochemistry (ICC/IF)

5 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide sequence (EPHVTRRTPDYFL) corresponding to the C-terminus amino acids of PPP2CA / PPP2CB
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Ammonium sulfate precipitation

Storage buffer

TBS, pH 7.3, with 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10986614

Product Specific Information

This antibody is predicted to react with bovine, canine, mouse, porcine, rabbit and rat based on sequence homology.

This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.

Target Information

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: phosphatase 2A; pp2A; PP2A-alpha; PP2A-beta; PPP2CA; PPP2CB; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform; protein phosphatase 2, catalytic subunit, alpha isozyme; protein phosphatase 2, catalytic subunit, beta isozyme; protein phosphatase 2,catalytic subunit alpha isozyme; protein phosphatase 2A alpha subunit; protein phosphatase 2A beta subunit; protein phosphatase 2A catalytic alpha subunit; protein phosphatase 2A catalytic subunit alpha isoform; protein phosphatase 2A catalytic subunit beta isoform; protein phosphatase 2A-beta catalytic subunit; protein phosphatase type 2A catalytic subunit; protein phosphatase-2A-alpha; protein phosphatase-2A-beta; replication protein C; RP C; Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; testicular tissue protein Li 146; type-2A protein phosphatase catalytic subunit; unnamed protein product

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Gene Aliases: D8Ertd766e; HJS3; NEDLBA; PP2A; Pp2a1; Pp2a2; PP2Abeta; PP2Ac; PP2CA; PP2Calpha; PP2CB; RP-C

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UniProt ID: (Pig) P67776, (Human) P67775, (Human) P62714, (Mouse) P63330, (Rat) P63331, (Mouse) P62715, (Rat) P62716

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Entrez Gene ID: (Pig) 397656, (Human) 5515, (Human) 5516, (Pig) 397136, (Mouse) 19052, (Rat) 24672, (Mouse) 19053, (Rat) 24673

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Function(s)
protein serine/threonine phosphatase activity protein C-terminus binding metal ion binding protein heterodimerization activity GABA receptor binding phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein binding hydrolase activity tau protein binding RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity ion channel binding enzyme binding protein kinase binding protein phosphatase binding protein domain specific binding beta-2 adrenergic receptor binding identical protein binding protein kinase B binding macromolecular complex binding protein phosphatase 2A binding protein antigen binding protein phosphatase
Process(es)
mesoderm development negative regulation of epithelial to mesenchymal transition peptidyl-threonine dephosphorylation meiotic cell cycle positive regulation of protein serine/threonine kinase activity mitotic cell cycle regulation of transcription from RNA polymerase II promoter protein dephosphorylation response to lead ion snRNA processing regulation of microtubule polymerization regulation of transcription elongation from RNA polymerase II promoter regulation of hippo signaling negative regulation of hippo signaling intracellular signal transduction regulation of growth T cell homeostasis regulation of cell differentiation negative regulation of protein kinase B signaling negative regulation of canonical Wnt signaling pathway vascular endothelial cell response to oscillatory fluid shear stress RNA polymerase II transcription initiation surveillance positive regulation of NLRP3 inflammasome complex assembly negative regulation of glycolytic process through fructose-6-phosphate regulation of G1/S transition of mitotic cell cycle negative regulation of gene expression negative regulation of tumor necrosis factor-mediated signaling pathway negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of Ras protein signal transduction regulation of neurofibrillary tangle assembly regulation of protein phosphorylation transcription from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter regulation of receptor activity regulation of protein autophosphorylation regulation of protein catabolic process positive regulation of glycolytic process regulation of cell cycle negative regulation of protein phosphorylation cardiac ventricle development heart development cellular response to insulin stimulus positive regulation of dephosphorylation negative regulation of protein import into nucleus cellular response to calcium ion cellular response to glucose stimulus cellular response to cytokine stimulus cellular response to ethanol cellular response to follicle-stimulating hormone stimulus cellular response to steroid hormone stimulus negative regulation of calcium ion transmembrane transporter activity positive regulation of extrinsic apoptotic signaling pathway apoptotic mitochondrial changes regulation of gene expression response to endoplasmic reticulum stress response to hydrogen peroxide proteasome-mediated ubiquitin-dependent protein catabolic process response to antibiotic
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