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Invitrogen
ATGL Polyclonal Antibody
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ATGL Antibody (PA5-18661) in WB
Western blot was performed using ATGL Polyclonal Antibody (Product # PA5-18661) and a 52 kDa band corresponding to ATGL was observed in adipose tissue only when compared to skeletal muscle. Whole cell extracts (30 µg lysate) of Rat adipose (Lane 1), Rat skeletal muscle (Lane 2) were electrophoresed using NuPAGE® 4-12 % Bis-Tris gel (Product # NP0321BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001). The blot was probed with the primary antibod... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-18661
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (PARPHGPEDKDQ) corresponding to the internal amino acids of PNPLA2 (aa 266-278).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is tested in Peptide ELISA: antibody detection limit dilution 8,000.
靶标信息
Lipolytic enzymes are required for mobilization of fatty acids from triglyceride stores in adipose tissue. Energy homeostasis is affected by dysfunctional lipolysis and may contribute to the pathogenesis of obesity and insulin resistance. Until recently, hormone-sensitive lipase (HSL) was the only enzyme known to hydrolyze triglycerides in mammalian adipose tissue. It is now thought that a second enzyme, adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammals.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Adipose triglyceride lipase; ATGL DESNUTRIN; Calcium-independent phospholipase A2-zeta; Desnutrin; DKFZp667M109; IPLA2 zeta; iPLA2-zeta; Patatin-like phospholipase domain-containing protein 2; PEDF R; PEDF-R; Pigment epithelium-derived factor receptor; plpl; plpl2; Transport-secretion protein 2; TTS 2.2; TTS2; TTS2.2
基因别名: ATGL; FP17548; PNPLA2
Entrez Gene ID: (Human) 57104
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