Invitrogen

Cullin 2 Polyclonal Antibody

Name: Cullin 2 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-19314
Availability: InStock

查看其他14个Cullin 2抗体

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

Additional Information:

抗体检测数据 (2)

Cullin 2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 2

Cullin 2 Antibody (PA5-19314) in IHC (P)

Immunohistochemistry analysis of Cullin 2 in human breast. Samples were incubated with Cullin 2 polyclonal antibody (Product # PA5-19314) using a dilution of 3.75 µg/mL. Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

Product Image Gallery

Immunogen image

Immunogen Image Cullin 2 Polyclonal Antibody

产品信息

PA5-19314

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-3 µg/mL

免疫组化（石蜡） (IHC (P))

3.75 µg/mL

产品规格

种属反应

Human, Mouse

宿主/亚型

Goat / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide sequence (QYIERSQASADE) corresponding to the C-terminus amino acids of CUL2 (aa 729-740).

3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

100 µg

纯化类型

Ammonium sulfate precipitation

保存液

TBS, pH 7.3, with 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_10982207

产品详细信息

This antibody is predicted to react with bovine, canine, human and rat based on sequence homology.

This antibody is tested in Peptide ELISA: antibody detection limit dilution 8,000.

靶标信息

Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). [UniProt]

仅用于科研。不用于诊断过程。未经明确授权不得转售。