Invitrogen

HLA-DQA1/DQA2 Polyclonal Antibody

Name: HLA-DQA1\/DQA2 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-19388

说明书

证书

实验方案

问题与答案

技术支持

说明书

证书

实验方案

问题与答案

技术支持

说明书

证书

实验方案

问题与答案

技术支持

Additional Information:

抗体检测数据 (1)

HLA-DQA1/DQA2 Antibody in Western Blot (WB)

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HLA-DQA1/DQA2 Antibody (PA5-19388) in WB

Western blot analysis of HLA-DQA1/DQA2 using HLA-DQA1/DQA2 Polyclonal Antibody (Product # PA5-19388) (1 µg/mL) in staining of Human Bone Marrow lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Product Image Gallery

Immunogen image

Immunogen Image HLA-DQA1/DQA2 Polyclonal Antibody

产品信息

PA5-19388

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-3 µg/mL

产品规格

种属反应

Human

宿主/亚型

Goat / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide sequence (QGLRSVGASRH) corresponding to the C-terminus amino acids of HLA-DQA2 (aa 241-251).

3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

100 µg

纯化类型

Ammonium sulfate precipitation

保存液

TBS, pH 7.3, with 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_10984364

产品详细信息

This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.

靶标信息

This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: DC-1 alpha chain; DC-alpha; DQ alpha; DQ alpha 2; DX alpha chain; HLA class II histocompatibility antigen DQ alpha chain; HLA class II histocompatibility antigen, DQ alpha 1 chain; HLA class II histocompatibility antigen, DQ alpha 2 chain; HLA class II histocompatibility antigen, DQ(6) alpha chain; HLA DQ-alpha; HLA-DCA; HLA-DQ alpha chain; HLA-DQA1; HLA-DQA2; human leukocyte antigen DQA1/DRA; MHC class I antigen; MHC class II antigen; MHC class II antigen DQA1; MHC class II DQ alpha chain; MHC class II DQ-alpha protein; MHC class II DQA1; MHC class II DQA2; MHC class II HLA-D alpha glycoprotein; MHC class II HLA-DQ-alpha-1; MHC class II protein; MHC DQ alpha protein precursor; MHC HLA-DQ alpha; MHC HLA-DQ-alpha chain precursor old gene name 'HLA-DQA'; MHC HLA-DQ-alpha precursor; MHC HLA-DQA1-alpha protein; unnamed protein product

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基因别名: CELIAC1; DC-alpha; DQ-A1; DQA1; DX-ALPHA; HLA-DCA; HLA-DQA; HLA-DQA1; HLA-DQA1*; HLA-DQA2; HLA-DQB1; HLA-DXA; HLADQA2

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UniProt ID: (Human) P01909, (Human) P01906

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Entrez Gene ID: (Human) 3117, (Human) 3118

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功能

protein binding MHC class II protein complex binding MHC class II receptor activity peptide antigen binding

参与通路

adaptive immune response immune system process peptide antigen assembly with MHC class II protein complex antigen processing and presentation of peptide or polysaccharide antigen via MHC class II immune response antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II positive regulation of immune response positive regulation of T cell activation