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Invitrogen
Beclin 1 Polyclonal Antibody
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图: 1 / 3
Beclin 1 Antibody (PA5-20172) in WB
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2023 -
Fig. 6 a-e Effect of Sert on autophagy of cerebral I/R in rats: a-d) Quantitative p-PI3K, p-mTOR, Beclin-1 and LC3II/I protein expression, e) Representative western blot bands showing expression of p-PI3K, p-mTOR, Beclin-1 and LC3II/I in different treatment groups. Results were illustrated as mean +- SE (n = 6). *: significant from Sham group (p < 0.05), # significant from Sert + Sham group (p < 0.05), ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-20172
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A peptide corresponding to 17 amino acids near the center of human Beclin-1. The immunogen is located between 40-90 amino acids of Beclin-1.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Suggested positive controls are mouse heart, mouse brain, or rat heart tissue lysates.
PA5-20172 can be used with blocking peptide PEP-0289.
Predicted species reactivity based on immunogen sequence: Bovine: (94%), Pig: (88%).
靶标信息
Beclin 1 plays a central role in autophagy. It acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Different PI3K complex forms are believed to play a role in multiple membrane trafficking pathways - PI3KC3-C1 is involved in the initation of autophagosomes and PI3KC3-C2 is involved in the maturation of autophagosomes and endocytosis. Beclin 1 also plays a role in antiviral host defense.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: APG6; Bcl-2-interacting protein beclin; beclin 1 (coiled-coil, myosin-like BCL2-interacting protein); Beclin-1; Coiled-coil myosin-like BCL2-interacting protein; coiled-coil, myosin-like BCL2-interacting protein; Protein GT197
基因别名: 4921513J16Rik; 5430417M23Rik; Atg6; Becn1
UniProt ID: (Rat) Q91XJ1, (Mouse) O88597
Entrez Gene ID: (Rat) 114558, (Mouse) 56208
autophagosome assembly
mitophagy
response to hypoxia
autophagy
cellular response to nitrogen starvation
lysosome organization
negative regulation of cell proliferation
positive regulation of autophagy
positive regulation of macroautophagy
CVT pathway
response to vitamin E
response to drug
nucleophagy
late endosome to vacuole transport
neuron development
beta-amyloid metabolic process
regulation of catalytic activity
defense response to virus
response to other organism
negative regulation of cell death
cellular response to aluminum ion
cellular response to epidermal growth factor stimulus
positive regulation of mitophagy
cytokinesis
angiogenesis
cell cycle
mitotic metaphase plate congression
macroautophagy
regulation of cytokinesis
receptor catabolic process
cellular response to glucose starvation
negative regulation of apoptotic process
cell division
mitophagy in response to mitochondrial depolarization
positive regulation of attachment of mitotic spindle microtubules to kinetochore
negative regulation of reactive oxygen species metabolic process
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
