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Invitrogen
CX3CL1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-20296
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A peptide corresponding to 18 amino acids near the amino terminus of human CX3CL1.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Despite the predicted molecular weight, CX3CL1 often migrates at 80-100kDa in SDS-PAGE, presumably due to post-translational modifications. A suggested positive control is C2C12 cell lysate.
PA5-20296 can be used with blocking peptide PEP-0398.
靶标信息
Chemokines are a family of proteins associated with the trafficking of leukocytes in immune surveillance and inflammatory cell recruitment. They are classified based on the positions of key cysteine residues. CX3CL1 is a CX3C chemokine known to induce adhesion and migration of leukocytes mediated by a membrane-bound and soluble form respectively. Recent experiments have shown that CX3CL1 can suppress the production of nitrous oxide, interleukin-6, and TNF-a in activated microglia and neuronal cells, suggesting that it may act as an intrinsic inhibitor against neurotoxicity by activated microglia. Its receptor, CX3CR1, also functions as a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by CX3CL1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ABCD-3; C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; FK; Fractalkine; Neurotactin; small inducible cytokine subfamily D, 1; Small-inducible cytokine D1
基因别名: AB030188; ABCD-3; AI848747; CX3C; Cx3cl1; Cxc3; D8Bwg0439e; Fkn; Scyd1
UniProt ID: (Mouse) O35188
Entrez Gene ID: (Mouse) 20312
microglial cell activation
positive regulation of neuroblast proliferation
chemotaxis
immune response
cell adhesion
positive regulation of macrophage chemotaxis
cytokine-mediated signaling pathway
platelet activation
positive regulation of cell migration
neutrophil chemotaxis
positive regulation of transforming growth factor beta1 production
wound healing
positive regulation of angiogenesis
positive regulation of cell adhesion
negative regulation of vasoconstriction
macrophage chemotaxis
lymphocyte chemotaxis
positive regulation of smooth muscle cell proliferation
negative regulation of cytokine secretion
leukocyte adhesive activation
positive regulation of calcium-independent cell-cell adhesion
angiogenesis involved in wound healing
inhibitory postsynaptic potential
cell chemotaxis
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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