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Invitrogen
TMP21 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-20316
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
An 18 amino acid peptide from near the center of human TMP21.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is mouse brain tissue lysate.
PA5-20316 can be used with blocking peptide PEP-0436.
Target Information
TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the -gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the -gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased -gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate -gamma-secretase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 21 kDa transmembrane-trafficking protein; integral membrane protein Tmp21-I (p23); p24 family protein delta-1; p24delta1; Protein Tmed10; Transmembrane emp24 domain-containing protein 10; Transmembrane protein Tmp21; transmembrane trafficking protein; transmembrane trafficking protein 21
Gene Aliases: 1110014C03Rik; p23; p24delta1; Tmed10; Tmp21
UniProt ID: (Rat) Q63584, (Mouse) Q9D1D4
Entrez Gene ID: (Rat) 84599, (Mouse) 68581
kidney development
intracellular protein transport
retrograde vesicle-mediated transport, Golgi to ER
vesicle targeting
Golgi organization
COPI-coated vesicle budding
response to alkaloid
regulated exocytosis
vesicle targeting, to, from or within Golgi
protein oligomerization
regulation of beta-amyloid formation
transport
protein transport
vesicle-mediated transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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