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Invitrogen
PARL Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-20579
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 15 amino acid peptide from near the amino terminus of human PARL.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Despite its predicted molecular weight of ~42kDa, PARL is observed at a higher molecular weight in SDS-PAGE. A suggested positive control is NIH-3T3 cell lysate.
PA5-20579 can be used with blocking peptide PEP-0699.
靶标信息
This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Mitochondrial intramembrane-cleaving protease PARL; parl {ECO:0000250|UniProtKB:Q9H300}; Presenilin-associated rhomboid-like protein, mitochondrial; presenilins-associated rhomboid-like protein, mitochondrial
基因别名: D16Ertd607e; Parl; PRO2207; Psarl; PSARL1; PSENIP2
UniProt ID: (Mouse) Q5XJY4, (Rat) Q3B8P0
Entrez Gene ID: (Mouse) 381038, (Rat) 287979
proteolysis
protein processing
regulation of proteolysis
negative regulation of release of cytochrome c from mitochondria
regulation of mitophagy
regulation of protein targeting to mitochondrion
regulation of reactive oxygen species metabolic process
negative regulation of intrinsic apoptotic signaling pathway
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