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Invitrogen
JMJD2A Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-20806
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 14 amino acid peptide from near the center of human JMJD2A.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
A suggested positive control is rat liver tissue lysate.
PA5-20806 can be used with blocking peptide PEP-0920.
靶标信息
JMJD2A is a member of the Jumonji domain 2 (JMJD2) family and a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: [histone H3]-trimethyl-L-lysine(36) demethylase 4A; [histone H3]-trimethyl-L-lysine(9) demethylase 4A; JmjC domain-containing histone demethylation protein 3A; jumonji domain containing 2A; Jumonji domain-containing protein 2A; Lysine-specific demethylase 4A
基因别名: D4Ertd222e; JHDM3A; Jmjd2; Jmjd2a; Kdm4a; Kiaa0677; mKIAA0677
UniProt ID: (Mouse) Q8BW72
Entrez Gene ID: (Rat) 313539, (Mouse) 230674
double-stranded DNA binding
zinc ion binding
ubiquitin protein ligase binding
histone demethylase activity
methylated histone binding
histone demethylase activity (H3-K36 specific)
sulfonate dioxygenase activity
oxidoreductase activity
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
procollagen-proline dioxygenase activity
hypophosphite dioxygenase activity
DNA-N1-methyladenine dioxygenase activity
metal ion binding
dioxygenase activity
C-19 gibberellin 2-beta-dioxygenase activity
C-20 gibberellin 2-beta-dioxygenase activity
histone modifying enzyme
positive regulation of gene expression
cardiac muscle hypertrophy in response to stress
histone demethylation
response to nutrient levels
positive regulation of neuron differentiation
negative regulation of transcription, DNA-templated
negative regulation of astrocyte differentiation
negative regulation of cell death
histone H3-K36 demethylation
transcription, DNA-templated
regulation of transcription, DNA-templated
chromatin modification
oxidation-reduction process
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