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Invitrogen
AGTR1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-20812
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Chicken,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 16 amino acid peptide from near the center of human AGTR1.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is mouse kidney tissue lysate.
PA5-20812 can be used with blocking peptide PEP-0926.
Target Information
AGTR1 is known as Angiotensin II Type 1 Receptor. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. And it acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. Moreover, this gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: angiotensin II type-1 receptor A; angiotensin II type-1A receptor; angiotensin receptor 1; angiotensin receptor 1a; AT1 receptor; AT1 receptor A; AT1A; type-1A angiotensin II receptor; type-1B angiotensin II receptor; unnamed protein product; vascular type-1 angiotensin II receptor
Gene Aliases: 1810074K20Rik; AG2S; Agt1ar; Agtr-1a; Agtr1; AGTR1B; Angtr-1a; AT1; AT1A; AT1AR; AT1B; AT1BR; AT1R; AT2R1; AT2R1A; ATR1; HAT1R
UniProt ID: (Human) P30556, (Mouse) P29754, (Rat) P25095
Entrez Gene ID: (Human) 185, (Mouse) 11607, (Rat) 24180
blood vessel development
positive regulation of cytokine production
kidney development
positive regulation of receptor recycling
regulation of systemic arterial blood pressure by circulatory renin-angiotensin
renin secretion into blood stream
renin-angiotensin regulation of aldosterone production
regulation of renal output by angiotensin
regulation of blood vessel size by renin-angiotensin
brain renin-angiotensin system
regulation of systemic arterial blood pressure by renin-angiotensin
protein phosphorylation
regulation of pH
inflammatory response
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
Rho protein signal transduction
heart development
regulation of blood pressure
positive regulation of cell proliferation
response to salt stress
gene expression
positive regulation of macrophage derived foam cell differentiation
response to activity
regulation of vasoconstriction
calcium-mediated signaling
positive regulation of superoxide anion generation
regulation of smooth muscle cell apoptotic process
negative regulation of smooth muscle cell apoptotic process
angiotensin-activated signaling pathway
vasoconstriction
dopamine biosynthetic process
drinking behavior
activation of Janus kinase activity
response to estrogen
positive regulation of angiogenesis
positive regulation of blood pressure
viral entry into host cell
response to corticosterone
cell chemotaxis
cellular response to dexamethasone stimulus
phospholipase C-activating angiotensin-activated signaling pathway
positive regulation of branching involved in ureteric bud morphogenesis
positive regulation of cholesterol metabolic process
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
positive regulation of calcium ion import across plasma membrane
response to angiotensin
regulation of cell growth
low-density lipoprotein particle remodeling
regulation of renal sodium excretion
regulation of cell proliferation
regulation of inflammatory response
positive regulation of inflammatory response
regulation of blood vessel diameter
positive regulation of reactive oxygen species metabolic process
regulation of blood volume by renin-angiotensin
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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