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Invitrogen
GOLPH3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-20830
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 14 amino acid peptide from near the amino terminus of human GOLPH3.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
A suggested positive control is rat lung tissue lysate.
PA5-20830 can be used with blocking peptide PEP-0944.
靶标信息
GOLPH3 was initially identified as a peripheral membrane protein localized to the trans-Golgi network, but others reported it to be primarily a mitochondrial protein that regulated the mitochondrial mass through the regulation of the mitochondria-specific phospholipid cardiolipin. GOLPH3 has since been implicated in the target of rapamycin (TOR) signaling pathway. Its overexpression in transfected cells led to and increase in anchorage-independent growth and cell proliferation in vitro. Furthermore, GOLPH3-transfected cells enhanced S6 Kinase activity in response to growth factor stimulation by EGF. Simultaneously, AKT phosphorylation increased in these cells, while these events were abrogated in GOLPH3 siRNA treated cells compared to control cells, indicating the GOLPH3 can enhance signaling through TOR-associated complexes. These results suggest that GOLPH3 is a bona fide oncogene and may be a useful target for therapeutic strategies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Coat protein GPP34; Golgi phosphoprotein 3; trans-Golgi protein GMx33
基因别名: 4733401N08Rik; 5730410D03Rik; AW413496; Gmx33; Golph3; Gpp34
UniProt ID: (Mouse) Q9CRA5
Entrez Gene ID: (Mouse) 66629, (Rat) 78961
transport
Golgi organization
cell proliferation
glycoprotein biosynthetic process
protein secretion
gene expression
regulation of mitochondrion organization
protein transport
cell migration
lamellipodium assembly
positive regulation of TOR signaling
Golgi to plasma membrane protein transport
negative regulation of apoptotic process
protein retention in Golgi apparatus
Golgi vesicle budding
positive regulation of protein secretion
leukocyte tethering or rolling
cell adhesion molecule production
Golgi ribbon formation
asymmetric Golgi ribbon formation
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
