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Invitrogen
SRPX Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-20843
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 13 amino acid peptide from near the amino terminus of human SRPX1.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
A suggested positive control is SK-N-SH cell lysate.
PA5-20843 can be used with blocking peptide PEP-0957.
靶标信息
SRPX1 was initially identified as a candidate gene for X-linked retinitis pigmentosa and is overexpressed in the trabecular network of the eye in glaucoma conditions. Its expression is significantly downregulated in a number cancer cell lines and malignant tumor tissues and its ectopic expression induces apoptosis through the endoplasmic reticulum and the activation of caspase-12, -9, and -3, indicating that it can function as a tumor suppressor. SRPX1 is also involved with the regulation of autophagy under low serum conditions and can associate with Rab24, a member of the Rab GTPase protein family that is involved in autophagy. This association of SRPX1 with Rab24 is enhanced during autophagy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: a novel protein with short consensus repeats of six cysteines; the protein has three short consensus repeats (SCR), which is a motif of approximately 60 amino acids; down-regulated by v-src; drs; epididymis secretory sperm binding protein Li 83p; sushi-repeat-containing protein, X chromosome; sushi-repeat-containing protein, X-chromosome; unnamed protein product
基因别名: DRS; DRS-1; DRS-2; ETX1; HEL-S-83p; SRPX1
UniProt ID: (Human) P78539, (Mouse) Q9R0M3, (Rat) Q63769
Entrez Gene ID: (Human) 8406, (Mouse) 51795, (Rat) 64316
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