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Invitrogen
MAEL Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-20923
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 16 amino acid peptide near the carboxy terminus of human Maelstrom.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is Hela cell lysate.
PA5-20923 can be used with blocking peptide PEP-1037.
Target Information
The mammalian homolog of the Drosophila protein Maelstrom is expressed in the male germline and localizes to the sex body in spermatocytes and the chromatid body in round spermatids. Similar to its expression in Drosophila, Maelstrom is a component of nuages, a germ-cell specific organelle and is thought to be essential for spermatogenesis and transposon repression during meiosis. In humans, Maelstrom has been found to be expressed only in the testis and in various cancer cell lines. Treatment of these cell lines with the demethylating agent 5'-Aza-2-Deoxycytidine significantly upregulated Maelstrom levels, indicating that its expression is regulated by DNA methylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: maelstrom homolog; Protein maelstrom homolog; RP11-102C16.1
Gene Aliases: 4933405K18Rik; AU019877; Mael; RGD1309333
UniProt ID: (Mouse) Q8BVN9
Entrez Gene ID: (Rat) 364039, (Mouse) 98558
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
cellular response to DNA damage stimulus
synapsis
male meiosis
spermatogenesis
intrinsic apoptotic signaling pathway in response to DNA damage
fertilization
negative regulation of gene expression
gene silencing by RNA
piRNA metabolic process
DNA methylation involved in gamete generation
negative regulation of apoptotic process
regulation of organ growth
multicellular organism development
cell differentiation
meiotic cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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