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Recommended positive controls: Jurkat, Raji, K562, C8D30, NIH-3T3, Raw264.7, C2C12, rat liver.
Predicted reactivity: Mouse (86%), Rat (84%), Dog (84%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
EMR1 has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. EMR1 is the human ortholog of murine F4/80 but unlike F4/80, the expression of EMR1 in humans is restricted to eosinophils and is not expressed on macrophage populations.
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