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Invitrogen
HNF1A Polyclonal Antibody
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图: 1 / 5
HNF1A Antibody (PA5-22310) in ICC/IF
HNF1A Polyclonal Antibody detects HNF1 alpha protein at nucleus by immunofluorescent analysis. Sample: HepG2 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: HNF1 alpha stained by HNF1A Polyclonal Antibody (Product # PA5-22310) diluted at 1:1,000. Blue: Fluoroshield with DAPI .
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-22310
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human HNF1 alpha. The exact sequence is proprietary.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.27 mg/mL
规格
127 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: HepG2, Mouse liver, Rat liver.
Predicted reactivity: Mouse (99%), Rat (99%), Xenopus laevis (83%), Pig (99%), Chicken (95%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: hepatocyte nuclear factor 1; Hepatocyte nuclear factor 1-alpha; hnf-1 alpha; HNF-1-alpha; HNF-1A; LFB1; Liver-specific transcription factor LF-B1; TCF-1; Transcription factor 1
基因别名: AI323641; Hnf-1; Hnf-1a; HNF1; HNF1-alpha; HNF1[a]; Hnf1a; Hnf1alpha; LFB1; Tcf-1; Tcf1
UniProt ID: (Mouse) P22361
Entrez Gene ID: (Mouse) 21405
RNA polymerase II core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription cofactor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
protein homodimerization activity
sequence-specific DNA binding
transcription regulatory region DNA binding
protein heterodimerization activity
protein dimerization activity
DNA-binding transcription factor
negative regulation of transcription from RNA polymerase II promoter
blastocyst development
liver development
placenta development
chromatin remodeling
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
fatty acid biosynthetic process
bile acid biosynthetic process
heme biosynthetic process
response to oxidative stress
protein localization
cholesterol metabolic process
response to glucose
bile acid and bile salt transport
fatty acid transport
insulin secretion
regulation of Wnt signaling pathway
embryonic limb morphogenesis
endocrine pancreas development
renal glucose absorption
glucose homeostasis
reverse cholesterol transport
bone resorption
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
glucose import
regulation of hormone secretion
paraxial mesoderm formation
reproductive structure development
regulation of insulin secretion
positive regulation of transcription initiation from RNA polymerase II promoter
SMAD protein signal transduction
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