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Invitrogen
TYRO3 Polyclonal Antibody
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图: 1 / 4
TYRO3 Antibody (PA5-22999) in ICC/IF
Immunocytochemistry analysis of TYRO3 in HeLa cells. Samples were incubated with TYRO3 polyclonal antibody (Product # PA5-22999) using a dilution of 1:200 followed by Dylight-488 conjugated goat anti-rabbit secondary antibody. Nuclei were visualized using Hoechst 33258 (Blue).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-22999
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide made to an internal portion of the human TYRO3 protein (within residues 100-250).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.19 mg/mL
规格
119 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 30% glycerol
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The target sequence has 94% sequence homology with rat.
Suggested positive control: normal human brain lysate, normal mouse brain lysate.
靶标信息
TYRO3 (tyrosine-protein kinase receptor TYRO3) is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. It regulates many physiological processes including cell survival, migration, and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by a ligand, TYRO3 plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation, signal transduction, cell adhesion. and cytoskeleton reorganization.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Etk2/tyro3; FLJ16467; soluble tyro 3; soluble tyro3; styro 3; styro3; TK19-2; tyro 3; Tyrosine-protein kinase DTK; Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase RSE; Tyrosine-protein kinase TIF
基因别名: AI323366; Brt; Dtk; Etk-2; etk2/tyro3; Rse; Sky; Tif; TK19-2; Tyro3
UniProt ID: (Mouse) P55144
Entrez Gene ID: (Mouse) 22174
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
phosphatidylinositol 3-kinase binding
protein heterodimerization activity
transmembrane signal receptor
natural killer cell differentiation
protein phosphorylation
cell adhesion
spermatogenesis
phosphorylation
peptidyl-tyrosine phosphorylation
forebrain cell migration
platelet activation
secretion by cell
negative regulation of toll-like receptor signaling pathway
substrate adhesion-dependent cell spreading
ovulation cycle
apoptotic cell clearance
protein kinase B signaling
negative regulation of neuron apoptotic process
negative regulation of innate immune response
protein autophosphorylation
negative regulation of inflammatory response
negative regulation of lymphocyte activation
vagina development
neuron cellular homeostasis
platelet aggregation
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