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          • Primary Antibodies ›
          • NOTCH1 Antibodies

          Invitrogen

          NOTCH1 Polyclonal Antibody

          查看其他42个NOTCH1抗体

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          Cite NOTCH1 Polyclonal Antibody

          Additional Information:
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          • 抗体检测数据 (1)
          NOTCH1 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.
          NOTCH1 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          图: 1 / 1

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          NOTCH1 Antibody (PA5-23181) in WB

          Western blot analysis of NOTCH1 in HEK293 cells transfected with full length Notch 1. Samples were incubated in NOTCH1 polyclonal antibody (Product # PA5-23181 using a dilution of 3 µg/mL. A) untreated and B) treated with 5 mM EDTA for 15 minutes. The EDTA treatment increases the detected level of Notch1-cv. {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
          已发表图片由___提供 benchsci-logo
          PMID: {{$ctrl.currentElement.benchSciPubmedId}}
          查看产品

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          NOTCH1 Antibody in Western Blot (WB)

          Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

          NOTCH1 Polyclonal Antibody

          产品信息

          PA5-23181

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          3-5 µg/mL
          -
          产品规格

          种属反应

          Bovine, Dog, Human, Mouse, Rat

          宿主/亚型

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          抗原

          Within the range of amino acids 1755-1780 of human Notch1.
          3D表位/免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          0.5 mg/mL

          规格

          100 µg

          纯化类型

          Protein G

          保存液

          PBS with 0.2% gelatin

          内含物

          0.05% sodium azide

          保存条件

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          运输条件

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2540707

          靶标信息

          The notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine-rich EGF-like repeats in the extracellular region. Four notch genes have been described in mammals: Notch1, Notch2, Notch3 and Notch4(Int-3), which have been implicated in the differentiation of the nervous system and other structures. The EGF-like proteins Delta and Serrate have been identified as ligands of Notch1. Mature Notch proteins are heterodimeric receptors derived from the cleavage of Notch pre-proteins into an extracellular subunit (NEC) containing multiple EGF-like repeats and a transmembrane subunit including intracellular region (Ntm).

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          篇参考文献 (0)

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          引用该产品

          生物信息学

          蛋白别名: Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila); major type A protein; Motch A; mT14; Neurogenic locus notch homolog protein 1; Notch 1; Notch gene homolog 1; Notch homolog 1, translocation-associated; NOTCH1; p300; RP23-306D20.12; RP23-306D20.12-001; TAN1; Translocation-associated notch protein TAN-1; transmembrane receptor Notch1; unnamed protein product

          查看更多 收起

          基因别名: 9930111A19Rik; AOS5; AOVD1; hN1; lin-12; Mis6; Motch; N1; NOTCH; NOTCH1; TAN1

          查看更多 收起

          UniProt ID: (Mouse) Q01705, (Rat) Q07008

          查看更多 收起

          Entrez Gene ID: (Bovine) 767866, (Dog) 480676, (Human) 4851, (Mouse) 18128, (Rat) 25496

          查看更多 收起

          功能
          chromatin binding transcription coactivator activity enzyme inhibitor activity transmembrane signaling receptor activity Notch binding calcium ion binding protein binding enzyme binding chromatin DNA binding signaling receptor activity identical protein binding transcription regulator activator activity core promoter binding transcriptional activator activity, RNA polymerase II transcription factor binding transcription factor activity, sequence-specific DNA binding receptor activity sequence-specific DNA binding metal ion binding protein heterodimerization activity extracellular matrix glycoprotein
          参与通路
          negative regulation of transcription from RNA polymerase II promoter luteolysis epithelial to mesenchymal transition heart looping positive regulation of neuroblast proliferation outflow tract morphogenesis endocardium development endocardium morphogenesis atrioventricular node development coronary vein morphogenesis aortic valve morphogenesis atrioventricular valve morphogenesis coronary sinus valve morphogenesis pulmonary valve morphogenesis mitral valve formation epithelial to mesenchymal transition involved in endocardial cushion formation endocardial cushion morphogenesis cardiac chamber formation cardiac ventricle morphogenesis cardiac atrium morphogenesis cardiac right atrium morphogenesis cardiac left ventricle morphogenesis ventricular trabecula myocardium morphogenesis growth involved in heart morphogenesis regulation of cardioblast proliferation cell migration involved in endocardial cushion formation negative regulation of extracellular matrix constituent secretion pericardium morphogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter protein import into nucleus immune response Notch signaling pathway positive regulation of transcription of Notch receptor target spermatogenesis determination of left/right symmetry axon guidance heart development positive regulation of cell proliferation negative regulation of cell proliferation gene expression negative regulation of cardiac muscle hypertrophy positive regulation of gene expression negative regulation of gene expression negative regulation of cardiac muscle cell apoptotic process positive regulation of epithelial to mesenchymal transition negative regulation of cell-substrate adhesion negative regulation of myotube differentiation mesenchymal cell development cell differentiation in spinal cord cell differentiation protein catabolic process negative regulation of ossification regulation of cell migration positive regulation of cell migration positive regulation of BMP signaling pathway negative regulation of BMP signaling pathway organ regeneration response to muramyl dipeptide response to lipopolysaccharide negative regulation of collagen biosynthetic process tube formation cellular response to vascular endothelial growth factor stimulus regulation of cell proliferation tissue regeneration negative regulation of catalytic activity positive regulation of viral genome replication positive regulation of endothelial cell differentiation negative regulation of myoblast differentiation negative regulation of neuron differentiation negative regulation of osteoblast differentiation positive regulation of glial cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of JAK-STAT cascade positive regulation of Ras protein signal transduction astrocyte differentiation oligodendrocyte differentiation positive regulation of astrocyte differentiation negative regulation of oligodendrocyte differentiation homeostasis of number of cells within a tissue negative regulation of neurogenesis regulation of developmental process positive regulation of smooth muscle cell differentiation cardiac muscle tissue morphogenesis cardiac muscle cell proliferation positive regulation of cardiac muscle cell proliferation negative regulation of glial cell proliferation cilium morphogenesis cardiac epithelial to mesenchymal transition negative regulation of cell adhesion molecule production cardiac muscle cell myoblast differentiation cardiac septum morphogenesis ventricular septum morphogenesis arterial endothelial cell differentiation venous endothelial cell differentiation cardiac vascular smooth muscle cell development endocardial cell differentiation vasculogenesis involved in coronary vascular morphogenesis coronary artery morphogenesis regulation of cell adhesion involved in heart morphogenesis heart trabecula morphogenesis positive regulation of cardiac epithelial to mesenchymal transition negative regulation of biomineral tissue development positive regulation of ERK1 and ERK2 cascade left/right axis specification cellular response to tumor cell cellular response to follicle-stimulating hormone stimulus cellular response to hypoxia distal tubule development collecting duct development glomerular mesangial cell development T-helper 17 type immune response negative regulation of cell migration involved in sprouting angiogenesis neuronal stem cell population maintenance interleukin-17-mediated signaling pathway chemical synaptic transmission, postsynaptic negative regulation of cold-induced thermogenesis regulation of extracellular matrix assembly positive regulation of apoptotic process involved in morphogenesis negative regulation of cell-cell adhesion mediated by cadherin negative regulation of cell proliferation involved in heart morphogenesis negative regulation of stem cell differentiation negative regulation of anoikis negative regulation of pro-B cell differentiation negative regulation of endothelial cell chemotaxis angiogenesis in utero embryonic development cell fate specification liver development sprouting angiogenesis osteoblast fate commitment inflammatory response to antigenic stimulus cardiac right ventricle formation regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation transcription, DNA-templated transcription from RNA polymerase II promoter humoral immune response multicellular organism development compartment pattern specification axonogenesis foregut morphogenesis endoderm development epidermis development regulation of Notch signaling pathway auditory receptor cell fate commitment glial cell differentiation regulation of gene expression regulation of somitogenesis neural tube development neuron differentiation keratinocyte differentiation lung development embryonic limb morphogenesis forebrain development hair follicle morphogenesis embryonic hindlimb morphogenesis skeletal muscle cell differentiation anagen positive regulation of apoptotic process cell fate commitment negative regulation of cell differentiation regulation of auditory receptor cell differentiation negative regulation of auditory receptor cell differentiation positive regulation of keratinocyte differentiation positive regulation of Notch signaling pathway negative regulation of calcium ion-dependent exocytosis negative regulation of photoreceptor cell differentiation somatic stem cell division neuron fate commitment branching morphogenesis of an epithelial tube regulation of epithelial cell proliferation positive regulation of epithelial cell proliferation regulation of neurogenesis secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development negative regulation of cell death prostate gland epithelium morphogenesis regulation of epithelial cell proliferation involved in prostate gland development Notch signaling involved in heart development positive regulation of transcription from RNA polymerase II promoter in response to hypoxia interleukin-4 secretion negative regulation of canonical Wnt signaling pathway positive regulation of ephrin receptor signaling pathway apoptotic process involved in embryonic digit morphogenesis brain development response to corticosteroid
          It has to be done as per old AB suggested Products section.

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