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Invitrogen
GRK5 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-23189
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A portion of amino acid 350-400 of human GRK5.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 0.2% gelatin
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
GRK5 is a serine/threonine kinase that regulates the activity of a variety of G protein-coupled receptors and the motility of polymorphonuclear leukocytes. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alpha-CP4; g protein-coupled receptor kinase GRK5; GRK; GRK-pan; Pan-GRK; unnamed protein product
Gene Aliases: 1200003L19Rik; AlphaCP-4; FP2025; GPRK5
UniProt ID: (Bovine) P43249, (Human) P34947, (Rat) Q62833, (Mouse) Q8VEB1, (Mouse) P57724
Entrez Gene ID: (Bovine) 281801, (Human) 2869, (Rat) 59075, (Mouse) 14773, (Mouse) 59092
protein serine/threonine kinase activity
G-protein coupled receptor kinase activity
ATP binding
lipid binding
beta-adrenergic receptor kinase activity
protein kinase activity
protein kinase C binding
protein binding
phospholipid binding
nucleic acid binding
RNA binding
mRNA binding
mRNA 3'-UTR binding
non-receptor serine/threonine protein kinase
apoptotic process
tachykinin receptor signaling pathway
positive regulation of cell proliferation
Wnt signaling pathway
negative regulation of apoptotic process
fat cell differentiation
protein autophosphorylation
regulation of cell cycle
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
regulation of G-protein coupled receptor protein signaling pathway
regulation of signal transduction
desensitization of G-protein coupled receptor protein signaling pathway
response to cocaine
oligodendrocyte differentiation
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
regulation of transcription from RNA polymerase II promoter
regulation of gene expression
regulation of mRNA stability
negative regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of mRNA splicing, via spliceosome
regulation of mRNA metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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