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Invitrogen
IL-12 p35 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-23226
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A portion of amino acids 200-219 of IL-12A.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Predicted to react with goat, pig.
靶标信息
Interleukin 12A is a novel signaling cytokine belonging to the Interleukin-6 protein superfamily. Interleukin-12 alpha chain precursor (IL-12A) is a 35-kD subunit of disulfide-linked heterodimer of cytokine IL-12 and has a broad array of biological activities. Reports suggest that IL-12A can act as a growth factor for activated T and NK cells and enhance the lytic activity of NK/lymphokine-activated Killer cells. IL-12A stimulates the production of IFN-gamma by resting PBMC as well as T-cell-independent induction of interferon (IFN)-gamma, and helps in the differentiation of both Th1 and Th2 cells. It is also involved in positive regulation of tyrosine phosphorylation of Stat4 protein. The signaling process of IL-12A in innate immunity requires nitric oxide synthase 2A. Along with EBI3, IL-12A forms a novel heterodimeric cytokine, designated as interleukin-35 (IL-35), that may be specifically produced by T reg cells and is required for maximal suppressive activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CLMF p35; cytotoxic lymphocyte maturation factor 1, p35; Cytotoxic lymphocyte maturation factor 35 kDa subunit; il 12; IL-12 subunit p35; IL-12, subunit p35; IL-12A; IL12p35; IL35 subunit; ILN; Interleukin; Interleukin 12; interleukin 12, p35; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); interleukin-12 alpha chain; Interleukin-12 subunit alpha; Interleukin12; NF cell stimulatory factor chain 1; NK cell stimulatory factor chain 1; NKSF/CLMF; IL12p35; 35kD; NKSF1
基因别名: CLMF; IL-12A; IL12A; NFSK; NKSF1; P35
Entrez Gene ID: (Human) 3592
positive regulation of T cell mediated cytotoxicity
negative regulation of T-helper 1 type immune response
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
immune response
response to virus
response to UV-B
cell migration
regulation of B cell proliferation
response to lipopolysaccharide
negative regulation of interleukin-17 production
positive regulation of interferon-gamma production
positive regulation of natural killer cell activation
positive regulation of natural killer cell proliferation
positive regulation of mononuclear cell proliferation
positive regulation of smooth muscle cell apoptotic process
interleukin-12-mediated signaling pathway
positive regulation of T cell proliferation
positive regulation of tyrosine phosphorylation of STAT protein
positive regulation of cell adhesion
positive regulation of natural killer cell mediated cytotoxicity
positive regulation of JAK-STAT cascade
negative regulation of smooth muscle cell proliferation
positive regulation of lymphocyte proliferation
negative regulation of protein secretion
defense response to Gram-positive bacterium
positive regulation of NK T cell activation
positive regulation of NK T cell proliferation
interleukin-35-mediated signaling pathway
extrinsic apoptotic signaling pathway
cellular response to virus
negative regulation of vascular endothelial growth factor signaling pathway
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
positive regulation of dendritic cell chemotaxis
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