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Invitrogen
Phospho-RAD17 (Ser645) Polyclonal Antibody
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Phospho-RAD17 (Ser645) Antibody (PA5-23330) in IHC (P)
Immunohistochemical analysis of Phospho-RAD17 (Ser645) in formalin-fixed, paraffin-embedded mouse liver tissue. Samples were incubated in Phospho-RAD17 (Ser645) polyclonal antibody (Product # PA5-23330) using a dilution of 5 µg/mL. Isotype control (top) and this antibody (bottom).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-23330
产品规格
种属反应
Human,
Mouse,
Non-human primate
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A portion of human Rad17 protein containing a phosphorylated serine residue at position 645.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.2 mg/mL
规格
20 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Rad17 is essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. It has a weak ATPase activity required for binding to chromatin. Rad17 also participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cell cycle checkpoint protein (RAD17); Cell cycle checkpoint protein RAD17; FLJ41520; hRad17; RAD1 homolog; RAD17 (Ser647); RAD17 homolog; Rad17 like protein; Rad17-like protein; RF-C activator 1 homolog; RF-C/activator 1 homolog; similar to checkpoint protein; unnamed protein product
基因别名: CCYC; HRAD17; MmRad24; R24L; RAD17; RAD17SP; RAD24
UniProt ID: (Mouse) Q6NXW6
Entrez Gene ID: (Human) 5884, (Mouse) 19356
DNA damage checkpoint
DNA repair
cellular response to DNA damage stimulus
cell cycle
mitotic cell cycle checkpoint
multicellular organism development
negative regulation of DNA replication
regulation of phosphorylation
DNA replication checkpoint
chromatin organization
intra-S DNA damage checkpoint
mitotic DNA replication checkpoint
protein localization to site of double-strand break
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