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Invitrogen

Nkx2.5 Polyclonal Antibody

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Nkx2.5 Polyclonal Antibody

Product Details

PA5-23387

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

5 µg/mL
-
Product Specifications

Species Reactivity

Human, Non-human primate

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A portion of amino acids 300-324 of human NKX2-5.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2540910

Product Specific Information

The amino acid sequence used as immunogen is 88% homologous in mouse, rat and opossum.

Target Information

This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cardiac-specific homeobox; cardiac-specific homeobox 1; FLJ52202; FLJ97166; FLJ97195; FLJ97197; FLJ99536; Homeobox protein CSX; Homeobox protein NK-2 homolog E; homeobox protein NKX 2-5; Homeobox protein Nkx-2.5; NK2 transcription factor related locus 5 (Drosophila) isoform NKX2-5_1; NK2 transcription factor related locus 5 (Drosophila) isoform NKX2-5_2; NK2 transcription factor related, locus 5; NKX 2-5; Nkx-2.5; Nkx-25; tinman homolog; tinman paralog; unnamed protein product

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Gene Aliases: CHNG5; CSX; CSX1; HLHS2; NKX2-5; NKX2.5; NKX2E; NKX4-1; VSD3

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Entrez Gene ID: (Human) 1482

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding protein homodimerization activity sequence-specific DNA binding RNA polymerase II sequence-specific DNA binding transcription factor binding sequence-specific double-stranded DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter vasculogenesis heart looping heart morphogenesis outflow tract septum morphogenesis cardiac conduction system development atrioventricular node development bundle of His development aortic valve morphogenesis right ventricular cardiac muscle tissue morphogenesis atrial cardiac muscle tissue development septum secundum development regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter adult heart development positive regulation of cell proliferation positive regulation of gene expression negative regulation of cardiac muscle cell apoptotic process positive regulation of sodium ion transport negative regulation of myotube differentiation hemopoiesis cell differentiation thyroid gland development embryonic heart tube development negative regulation of apoptotic process positive regulation of neuron differentiation positive regulation of heart contraction negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter spleen development positive regulation of cardioblast differentiation cardiac muscle cell differentiation cardiac muscle tissue morphogenesis cardiac muscle cell development atrial cardiac muscle cell development ventricular cardiac muscle cell development regulation of cardiac muscle contraction pharyngeal system development positive regulation of transcription initiation from RNA polymerase II promoter cardiac septum morphogenesis ventricular septum morphogenesis atrial septum morphogenesis negative regulation of canonical Wnt signaling pathway regulation of cardiac conduction
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