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Invitrogen
APH1 Polyclonal Antibody
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APH1 Antibody (PA5-23466) in WB
Western blot analysis of APH1 in human lung lysate. Samples were incubated with APH1 polyclonal antibody (Product # PA5-23466) followed by Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution. 1) human lung lysate using prebleed at 1:5,000, 2) human lung lysate.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-23466
产品规格
种属反应
Bovine,
Dog,
Horse,
Human,
Marsupial,
Non-human primate
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A portion of amino acids 80-145 of human APH1A.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The amino acid sequence used as immunogen is 88% homologous in Chicken.
靶标信息
APH1 is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). The gamma-secretase complex is minimally composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2, although other components may exist. APH1 probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: anterior pharynx defective 1 homolog A; APH1A gamma secretase subunit; RP4-790G17.3
基因别名: APH1
Entrez Gene ID: (Horse) 100054581, (Bovine) 539247, (Dog) 100855839
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
