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Invitrogen
DACH1 Polyclonal Antibody
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DACH1 Antibody (PA5-23483) in IHC (P)
Immunohistochemical analysis of DACH1 in formalin-fixed, paraffin-embedded human kidney tissue. Samples were incubated in DACH1 polyclonal antibody (Product # PA5-23483) using a dilution of 5 µg/mL. Isotype control (top left) and this antibody (bottom left, right).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-23483
产品规格
种属反应
Bovine,
Dog,
Chicken,
Horse,
Human,
Mouse,
Non-human primate
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Amino acids 474-501 of human Dach1.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The amino acid sequence used as immunogen is 83% homologous in Zebrafish.
靶标信息
Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: dac homolog; Dach1; Dachshund homolog 1; FLJ10138; nuclear factor; OTTHUMP00000040839; RP11-512J14.1; transcription factor; Drosophila melanogaster dachshund homolog
基因别名: Dac; DACH; DACH1
UniProt ID: (Mouse) Q9QYB2
Entrez Gene ID: (Horse) 100065685, (Dog) 485489, (Chicken) 373935, (Human) 1602, (Mouse) 13134
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
winged helix/forkhead transcription factor
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter
negative regulation of cell migration
regulation of nuclear cell cycle DNA replication
negative regulation of transcription, DNA-templated
negative regulation of DNA biosynthetic process
suckling behavior
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
respiratory gaseous exchange
cell proliferation
negative regulation of transcription by competitive promoter binding
development of primary female sexual characteristics
negative regulation of fibroblast proliferation
RNA polymerase II transcriptional preinitiation complex assembly
negative regulation of cell proliferation involved in contact inhibition
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