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Invitrogen
FUS Polyclonal Antibody
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图: 1 / 11
FUS Antibody (PA5-23696) in ICC/IF
Immunocytochemistry analysis of FUS in MDA-MB231 cells. Samples were incubated in FUS polyclonal antibody (Product # PA5-23696) followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-23696
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 499-526 amino acids from the C-terminal region of human FUS
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
200 µg
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is predicted to react with bovine based on sequence homology.
靶标信息
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 75 kDa DNA-pairing protein; FUS; fus-like protein; fused in sarcoma; fusion gene in myxoid liposarcoma; fusion, derived from t(12;16) malignant liposarcoma; heterogeneous nuclear ribonucleoprotein P2; hnRNP P2; nuclear RNA-binding protein; Oncogene FUS; Oncogene TLS; pigpen protein; POMp75; Protein pigpen; RNA-binding protein FUS; translocated in liposarcoma; Translocated in liposarcoma protein; unnamed protein product
基因别名: ALS6; altFUS; D430004D17Rik; D930039C12Rik; ETM4; FUS; FUS1; HNRNPP2; POMP75; TLS
UniProt ID: (Mouse) P56959
Entrez Gene ID: (Human) 2521, (Mouse) 233908
nucleic acid binding
chromatin binding
transcription cofactor activity
transcription coactivator activity
RNA binding
mRNA 3'-UTR binding
protein binding
identical protein binding
molecular condensate scaffold activity
nucleotide binding
DNA binding
zinc ion binding
estrogen receptor binding
myosin V binding
ionotropic glutamate receptor binding
metal ion binding
retinoid X receptor binding
thyroid hormone receptor binding
RNA metabolism protein
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
RNA splicing
regulation of RNA splicing
positive regulation of transcription, DNA-templated
mRNA stabilization
protein homooligomerization
membraneless organelle assembly
positive regulation of double-strand break repair via homologous recombination
amyloid fibril formation
cellular response to calcium ion
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
