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Invitrogen
Bcl-10 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-24191
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 24-51 amino acids from the N-terminal region of human BCL10
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with rat based on sequence homology.
Target Information
BCL-10 is an N-terminal CARD (Caspase Recruitment Domain) containing protein that is involved in the adaptive immune response. It promotes apoptosis, pro-caspase-9 maturation, and activation of NF-kappa-B via NIK and IKK. BCL-10 is also an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. It is a substrate for MALT1. Mutations in the gene can lead to Immmunodeficiency 37 or Lymphoma, mucosa-associated lymphoid type.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B-cell CLL/lymphoma 10; B-cell leukemia/lymphoma 10; B-cell lymphoma/leukemia 10; Bcl-10; c-E10; CARD-containing molecule enhancing NF-kappa-B; CARD-like apoptotic protein; cCARMEN; CED-3/ICH-1 prodomain homologous E10-like regulator; Cellular homolog of vCARMEN; Cellular-E10; Mamm; Mammalian CARD-containing adapter molecule E10; mCIPER; mCLAP; mE10; OTTHUMP00000011647; OTTHUMP00000036080; RP11-234D19.2
Gene Aliases: AI132454; BCL-10; Bcl10; C81403; CARMEN; cE10; CIPER; CLAP; ME10
UniProt ID: (Mouse) Q9Z0H7
Entrez Gene ID: (Mouse) 12042
protease binding
transcription coactivator activity
protein binding
protein C-terminus binding
transcription factor binding
cysteine-type endopeptidase activator activity involved in apoptotic process
kinase activator activity
enzyme binding
kinase binding
protein kinase binding
ubiquitin protein ligase binding
protein homodimerization activity
ubiquitin binding
protein kinase B binding
protein self-association
protein heterodimerization activity
NF-kappaB binding
B cell apoptotic process
neural tube closure
adaptive immune response
immune system process
negative regulation of mature B cell apoptotic process
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
cellular defense response
I-kappaB kinase/NF-kappaB signaling
activation of JUN kinase activity
cell death
response to fungus
immunoglobulin mediated immune response
positive regulation of protein ubiquitination
response to food
positive regulation of phosphorylation
regulation of apoptotic process
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
fibroblast apoptotic process
positive regulation of interleukin-8 biosynthetic process
mast cell activation
positive regulation of transcription, DNA-templated
T cell receptor signaling pathway
regulation of T cell receptor signaling pathway
positive regulation of T cell activation
positive regulation of NF-kappaB transcription factor activity
protein oligomerization
protein homooligomerization
protein heterooligomerization
T cell apoptotic process
thymocyte apoptotic process
positive regulation of execution phase of apoptosis
positive regulation of extrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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