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Invitrogen

HSC70 Polyclonal Antibody

Advanced Verification
2 Published Figures
2 References
View all (30) HSC70 antibodies

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HSC70 Polyclonal Antibody

Product Details

PA5-24624

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:10-1:50
-

Immunocytochemistry (ICC/IF)

1:10-1:50
-

Flow Cytometry (Flow)

1:10-1:50
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Non-human primate

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide between 82-110 amino acids from the N-terminal region of human HSPA8
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.5 mg/mL

Amount

600 µg

Purification

Ammonium sulfate precipitation, Size-exclusion - Dialysis

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2542124

Product Specific Information

This antibody is predicted to react with bovine, chicken, hamster, mouse and rat based on sequence homology.

Target Information

The HSP70 family is a set of highly conserved proteins that are induced by a variety of biological stresses, including heat stress, in every organism in which the proteins have been examined. The human HSP70 family members include: HSP70, a protein which is strongly inducible in all organisms but which is also constitutively expressed in primate cells; HSP72, a 72 kDa protein that is induced exclusively under stress conditions; HSC70, or cognate protein, is a 72 kDa, constitutively expressed, protein which is involved in the uncoating of clathrin coated vesicles; GRP78, or BiP, is a glucose regulated 78 kDa protein localized in the endoplasmic reticulum; and p75, or HSP75, a 75 kDa protein that is found within the mitochondria. HSC70 (also known as HSC71, HSC73, HSP73, p72, prp73) is expressed constitutively and is slightly heat-inducible. HSC70 binds to the exposed loop of clathrin light chains to promote uncoating and can also bind the cytoskeleton which may facilitate cytoskeletal rearrangements. HSC70 has been shown to stimulate lysosomal degradation of intracellular proteins and to retard both aggregation and folding of mitochondrial precursor proteins in vitro.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 70 kDa heat-shock-like protein; AAG2; ARABIDOPSIS THALIANA HEAT SHOCK COGNATE PROTEIN 70-1; AT-HSC70-1; AtHsp70-1; constitutive heat shock protein 70; epididymis luminal protein 33; epididymis secretory sperm binding protein Li 72p; FAM10A1; heat shock 70 kDa protein 8; heat shock 70kd protein 10; heat shock 70kD protein 8; heat shock 70kDa protein 8; heat shock cognate hsc73; heat shock cognate protein 54; HEAT SHOCK COGNATE PROTEIN 70; heat shock cognate protein 70-1; heat shock protein 70 cognate; HEAT SHOCK PROTEIN 70-1; heat shock protein 8; heat shock protein A8; heat shock protein cognate 70; heat shock protein family A member 8; HIP; HSC70; HSP70-1; LAP; lipopolysaccharide-associated protein 1; LPS-associated protein 1; MGC131511; MGC29929; N-myristoyltransferase inhibitor protein 71; Protein FAM10A1; SNC6; T22P11.90; T22P11_90; unnamed protein product

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Gene Aliases: 2410008N15Rik; HEL-33; HEL-S-72p; HSC54; HSC70; HSC71; Hsc73; HSP71; HSP73; HSPA10; LAP-1; LAP1; NIP71

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UniProt ID: (Human) P11142, (Mouse) P63017, (Rat) P63018

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Entrez Gene ID: (Human) 3312, (Mouse) 15481, (Rat) 24468

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Function(s)
G-protein coupled receptor binding RNA binding protein binding ATP binding ATPase activity enzyme binding MHC class II protein complex binding protein binding, bridging heat shock protein binding ubiquitin protein ligase binding protein binding involved in protein folding cadherin binding receptor agonist activity chaperone binding C3HC4-type RING finger domain binding ATP-dependent protein disaggregase activity ATP-dependent protein folding chaperone phosphatidylserine binding receptor binding lipid binding A1 adenosine receptor binding AP-3 adaptor complex binding peptide binding lncRNA binding prostaglandin binding clathrin-uncoating ATPase activity
Process(es)
G1/S transition of mitotic cell cycle mRNA splicing, via spliceosome kidney development positive regulation of T cell mediated cytotoxicity protein folding protein import into nucleus autophagy signal transduction skeletal muscle tissue development axo-dendritic transport response to xenobiotic stimulus response to nickel cation positive regulation of gene expression negative regulation of cardiac muscle cell apoptotic process response to activity cerebellum development protein catabolic process positive regulation of cell migration forebrain development regulation of protein stability response to estradiol response to progesterone protein-containing complex disassembly cellular response to heat protein refolding response to starvation positive regulation of catalytic activity intracellular protein transmembrane import modulation by host of viral process positive regulation by host of viral genome replication estrous cycle response to ethanol positive regulation of proteolysis negative regulation of transcription, DNA-templated ATP metabolic process protein autophosphorylation positive regulation of mRNA splicing, via spliceosome positive regulation of phagocytosis regulation of cell cycle regulation of protein complex stability chaperone-mediated autophagy late endosomal microautophagy protein targeting to lysosome involved in chaperone-mediated autophagy cellular response to hydrogen peroxide cellular response to cadmium ion clathrin coat disassembly positive regulation of lysosomal membrane permeability maintenance of postsynaptic specialization structure regulation of postsynapse organization positive regulation of ferroptosis negative regulation of NLRP3 inflammasome complex assembly negative regulation of fibril organization positive regulation of protein refolding chaperone-mediated autophagy translocation complex disassembly slow axonal transport response to odorant response to stress response to unfolded protein cellular response to starvation negative regulation of signal transduction regulation of cytoplasmic pattern recognition receptor signaling pathway regulation of programmed cell death regulation of protein complex assembly negative regulation of cellular component organization membrane organization cellular response to steroid hormone stimulus regulation of fibril organization regulation of protein import
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