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Invitrogen
HSP90 beta Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-27410
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fruit fly,
Human,
Mouse,
Rat,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human HSP90 beta. The exact sequence is proprietary.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
5.43 mg/mL
Amount
543 µg
Purification
Protein A
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: HeLaS3, Neuro2A, C8D30, NIH-3T3, Raw264.7, C2C12, PC-12, Rat-2.
Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (92%), Xenopus laevis (95%), Pig (100%), Chicken (96%), Rhesus Monkey (100%), Chimpanzee (99%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Heat shock proteins (HSP) are expressed in response to various biological stresses, including heat. HSP90 is a 90 kDa protein that is induced under stress conditions, but is also one of the most abundant cellular proteins found under non-stress conditions. HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90 has been found to be associated with a number of other intracellular proteins, including steroid receptors, actin, tubulin, aryl hydrocarbon (Ah) receptor, and some kinases.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AT20544p; CG1242-PA; CG1242-PB; enhancer of seven in absentia 2; enhancer of sevenless 3A; Heat shock 84 kDa; heat shock 90kDa protein 1, beta; Heat shock protein; heat shock protein 1, beta; Heat shock protein 83; heat shock protein 90-beta; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein 90kDa alpha, class B member 1; Heat shock protein family C member 3; Heat shock protein HSP 90-beta; heat shock protein, 84 kDa 1; heat-shock protein 90 kDa; HSP; HSP 82; HSP 84; HSP 90; hsp83; Hsp83-PA; Hsp83-PB; HSP84; retinal degeneration slow protein; RP1-302G2.1; scratch; TSTA; Tumor-specific transplantation 84 kDa antigen
Gene Aliases: 143198_at; 83; 83K HSP; 90kDa; AL022974; anon-EST:Liang-2.53; anon-WO0068693; anon-WO0140519.209; C81438; CG1242; clone 2.53; Dmel\CG1242; Dmel_CG1242; DMHSP82; DmHsp83; E(sev)3A; E(sina)2; en(lz)3C/4C; HSP82; HSP83; Hsp84; Hsp84-1; HSP90; HSP90-BETA; HSP90A1; HSP90AB1; HSP90B; hsp90beta; HSPC2; HSPC3; HSPCB; l(3)j5C2; ms(3)08445; ORF1; P02828; stc; Su(Raf)3A; wu:fa29f01; wu:fa91e11; wu:fd59e11; wu:gcd22h07
UniProt ID: (Fruit fly) P92174, (Mouse) P11499, (Rat) P34058, (Zebrafish) O57521
Entrez Gene ID: (Fruit fly) 38389, (Mouse) 15516, (Rat) 301252, (Zebrafish) 30573
insulin receptor binding
ATP binding
TPR domain binding
unfolded protein binding
disordered domain specific binding
nucleotide binding
UTP binding
CTP binding
double-stranded RNA binding
protein binding
GTP binding
sulfonylurea receptor binding
kinase binding
protein kinase binding
MHC class II protein complex binding
dATP binding
ion channel binding
poly(A) RNA binding
protein dimerization activity
Hsp90 family chaperone
positive regulation of neuroblast proliferation
protein folding
centrosome cycle
negative regulation of cell proliferation
response to heat
cold acclimation
negative regulation of transposition
pole plasm mRNA localization
cellular response to heat
proteasome assembly
regulation of circadian sleep/wake cycle, sleep
positive regulation of insulin receptor signaling pathway
oogenesis
protein stabilization
placenta development
response to stress
virion attachment to host cell
positive regulation of protein binding
positive regulation of protein import into nucleus, translocation
negative regulation of neuron apoptotic process
positive regulation of cell size
cellular response to interleukin-4
positive regulation of protein serine/threonine kinase activity
fibril organization
response to unfolded protein
response to salt stress
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of interferon-gamma-mediated signaling pathway
regulation of type I interferon-mediated signaling pathway
cellular response to organic cyclic compound
blood vessel development
muscle organ development
positive regulation of transforming growth factor beta receptor signaling pathway
response to estrogen
leukocyte migration
negative regulation of cell cycle arrest
negative regulation of transforming growth factor beta activation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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