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Invitrogen
DHCR24 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-27944
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human Seladin 1. The exact sequence is proprietary.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.29 mg/mL
规格
129 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: A431, H1299, mouse brain.
Predicted reactivity: Mouse (95%), Rat (95%), Zebrafish (82%), Xenopus laevis (81%), Pig (95%), Chicken (80%), Bovine (96%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
DHCR24 is a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. This protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of its gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 24-dehydrocholesterol reductase; 3-beta-hydroxysterol Delta-24-reductase; Delta(24)-sterol reductase; Diminuto/dwarf1 homolog; Seladin-1
基因别名: DHCR24; KIAA0018
UniProt ID: (Rat) Q5BQE6
Entrez Gene ID: (Rat) 298298
delta24(24-1) sterol reductase activity
UDP-N-acetylmuramate dehydrogenase activity
oxidoreductase activity
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
enzyme binding
peptide antigen binding
delta24-sterol reductase activity
flavin adenine dinucleotide binding
reductase
cholesterol biosynthetic process
response to oxidative stress
Ras protein signal transduction
protein localization
steroid metabolic process
cholesterol metabolic process
negative regulation of cell proliferation
response to hormone
tissue development
sterol metabolic process
male genitalia development
plasminogen activation
amyloid precursor protein catabolic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
skin development
oxidation-reduction process
membrane organization
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
