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Invitrogen
XPD Polyclonal Antibody
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图: 1 / 4
XPD Antibody (PA5-28236) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of XPD was performed in Mock and treated HeLa cells fixed in 4% paraformaldehyde at RT for 15 min. Green: XPD Polyclonal Antibody (Product # PA5-28236) diluted at 1:500. Blue: Hoechst 33342 staining. Scale bar = 10 µm.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-28236
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human XPD. The exact sequence is proprietary.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: IMR32, U87-MG.
Predicted reactivity: Mouse (98%), Rat (99%), Chimpanzee (100%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
XPD is involved with the nucleotide excision repair pathway that is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Basic transcription factor 2 80 kDa subunit; BTF2 p80; CXPD; DNA 5'-3' helicase XPD; DNA excision repair protein ERCC-2; DNA repair protein complementing XP-D cells; General transcription and DNA repair factor IIH helicase subunit XPD; MGC102762; MGC126218; MGC126219; TFIIH 80 kDa subunit; TFIIH basal transcription factor complex 80 kDa subunit; TFIIH basal transcription factor complex helicase subunit; TFIIH basal transcription factor complex helicase XPD subunit; TFIIH subunit XPD; Xeroderma pigmentosum group D-complementing protein
基因别名: AA407812; AU020867; AW240756; CXPD; Ercc-2; ERCC2; XPD; XPDC
UniProt ID: (Mouse) O08811
Entrez Gene ID: (Mouse) 13871
nucleotide binding
nucleic acid binding
DNA binding
ATP-dependent DNA helicase activity
helicase activity
protein kinase activity
ATP binding
protein C-terminus binding
ATP-dependent helicase activity
DNA-dependent ATPase activity
RNA polymerase II carboxy-terminal domain kinase activity
hydrolase activity
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
5'-3' DNA helicase activity
metal ion binding
protein N-terminus binding
iron-sulfur cluster binding
4 iron, 4 sulfur cluster binding
DNA helicase
in utero embryonic development
nucleobase-containing compound metabolic process
DNA repair
transcription-coupled nucleotide-excision repair
nucleotide-excision repair
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
protein phosphorylation
apoptotic process
cellular response to DNA damage stimulus
response to oxidative stress
chromosome segregation
aging
cell proliferation
response to UV
UV protection
post-embryonic development
spinal cord development
hair cycle process
extracellular matrix organization
bone mineralization
central nervous system myelin formation
DNA duplex unwinding
nucleotide-excision repair, DNA incision
multicellular organism growth
hair cell differentiation
embryonic cleavage
erythrocyte maturation
positive regulation of DNA binding
skin development
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
hair follicle maturation
hematopoietic stem cell differentiation
regulation of mitotic cell cycle phase transition
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