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Invitrogen
Bcl-10 Polyclonal Antibody
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Bcl-10 Antibody (PA5-28946) in IHC (P)
Bcl-10 Polyclonal Antibody detects BCL10 protein at cytoplasm on human breast carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human breast carcinoma. Bcl-10 Polyclonal Antibody (Product # PA5-28946) diluted at 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-28946
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Full length human BCL10 Recombinant protein.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.45 mg/mL
规格
45 µg
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji, NIH-3T3.
Predicted reactivity: Mouse (90%), Rat (91%), Pig (92%), Rhesus Monkey (99%), Bovine (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
BCL-10 is an N-terminal CARD (Caspase Recruitment Domain) containing protein that is involved in the adaptive immune response. It promotes apoptosis, pro-caspase-9 maturation, and activation of NF-kappa-B via NIK and IKK. BCL-10 is also an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. It is a substrate for MALT1. Mutations in the gene can lead to Immmunodeficiency 37 or Lymphoma, mucosa-associated lymphoid type.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: B-cell CLL/lymphoma 10; B-cell leukemia/lymphoma 10; B-cell lymphoma/leukemia 10; Bcl-10; c-E10; CARD-containing molecule enhancing NF-kappa-B; CARD-like apoptotic protein; cCARMEN; CED-3/ICH-1 prodomain homologous E10-like regulator; Cellular homolog of vCARMEN; Cellular-E10; CIPER; hCLAP; Mamm; Mammalian CARD-containing adapter molecule E10; mCIPER; mCLAP; mE10; OTTHUMP00000011647; OTTHUMP00000036080; RP11-234D19.2
基因别名: AI132454; BCL-10; BCL10; C81403; CARMEN; cE10; CIPER; CLAP; ME10
UniProt ID: (Mouse) Q9Z0H7
Entrez Gene ID: (Mouse) 12042
protease binding
transcription coactivator activity
protein binding
protein C-terminus binding
transcription factor binding
cysteine-type endopeptidase activator activity involved in apoptotic process
kinase activator activity
enzyme binding
kinase binding
protein kinase binding
ubiquitin protein ligase binding
protein homodimerization activity
ubiquitin binding
protein kinase B binding
protein self-association
protein heterodimerization activity
NF-kappaB binding
B cell apoptotic process
neural tube closure
adaptive immune response
immune system process
negative regulation of mature B cell apoptotic process
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
cellular defense response
I-kappaB kinase/NF-kappaB signaling
activation of JUN kinase activity
cell death
response to fungus
immunoglobulin mediated immune response
positive regulation of protein ubiquitination
response to food
positive regulation of phosphorylation
regulation of apoptotic process
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
fibroblast apoptotic process
positive regulation of interleukin-8 biosynthetic process
mast cell activation
positive regulation of transcription, DNA-templated
T cell receptor signaling pathway
regulation of T cell receptor signaling pathway
positive regulation of T cell activation
positive regulation of NF-kappaB transcription factor activity
protein oligomerization
protein homooligomerization
protein heterooligomerization
T cell apoptotic process
thymocyte apoptotic process
positive regulation of execution phase of apoptosis
positive regulation of extrinsic apoptotic signaling pathway
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