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Invitrogen
Tyrosine Hydroxylase Polyclonal Antibody
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图: 1 / 15
Tyrosine Hydroxylase Antibody (PA5-29617) in ICC/IF
Tyrosine Hydroxylase Polyclonal Antibody detects Tyrosine Hydroxylase protein at cytoplasm by immunofluorescent analysis. Sample: U-87 MG cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: Tyrosine Hydroxylase protein stained by Tyrosine Hydroxylase Polyclonal Antibody (Product # PA5-29617) diluted at 1:400. Red: beta Tubulin 3/ TUJ1 protein stained by beta-3 Tubulin Polyclonal Antibody dilute... View More
产品信息
PA5-29617
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 150 and 490 of Human Tyrosine Hydroxylase
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
保存条件
-20°C
运输条件
Wet ice
产品详细信息
PA5-29617 targets Tyrosine Hydroxylase in IF, IHC (P, F), and WB applications and shows reactivity with Human, mouse and Rat samples.
The PA5-29617 immunogen is recombinant fragment corresponding to a region within amino acids 150 and 490 of Human Tyrosine Hydroxylase.
靶标信息
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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