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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Recommended positive controls: NT2D1, RD, mouse muscle, rat muscle.
Predicted reactivity: Mouse (97%), Rat (97%), Chicken (84%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: cypher; FLJ35865; HGNC:15710; KIAA01613; ldb3; LIM domain-binding protein 3; oracle protein; PDZ-LIM domain protein; Protein cypher; Protein oracle; Z-band alternatively spliced PDZ-motif protein
基因别名: AW742271; KIAA0613; LDB3; PDLIM6; RGD1564875; ZASP
UniProt ID: (Mouse) Q9JKS4
Entrez Gene ID: (Mouse) 24131, (Rat) 498587