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Invitrogen
CRHR1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-32712
Product Specifications
Species Reactivity
Dog,
Horse,
Hamster,
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 15 amino acid peptide from N-terminal extracellular domain of human CRF1.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Dog, Hamster, Panda, Horse (100%); Bat, Bovine, Pig, Opossum (93%); Elephant (87%); Sheep, Lizard (80%).
For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
Corticotropin-releasing factor receptor 1 (CRFR1/CRHR1), a Corticotropin-Releasing Factor Receptor, is involved in mediating the stress response and anxiety-related behaviors. Mutations of the receptor reduce anxiety-related behaviors and may be involved in the pathogenesis of Cushing disease. Multiple isoforms of CRFR1 are produced by alternative splicing. CRFR1 has been reported to be expressed in the pituitary, adrenal gland, brain, colon, ovary, placenta, testis, white blood cells, and skin. ESTs have been isolated from human brain, eye, colon, and embryo libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: corticotrophin releasing hormone receptor 1; corticotropin releasing hormone 1; corticotropin-releasing factor receptor 1; corticotropin-releasing factor receptor variant 1j; corticotropin-releasing factor type 1 receptor; CRF 1 receptor; Crf receptor 1; Crf type 1; Crf1 receptor; CRF1a-desK; CRF1I; CRH-R1d; type 1 CRH receptor; CRH-R1h; CRHR1c; CRHR1e; CRHR1f; CRHR1g; G protein-coupled receptor; seven transmembrane helix receptor; unnamed protein product
Gene Aliases: CRF-R; CRF-R-1; CRF-R1; CRF-R1alpha; CRF1; CRF1R; CRFR-1; CRFR1; CRH-R; CRH-R 1; CRH-R-1; CRH-R1; CRHR; CRHR1L
UniProt ID: (Human) P34998, (Mouse) P35347, (Rat) P35353
Entrez Gene ID: (Human) 1394, (Mouse) 12921, (Rat) 58959
transmembrane signaling receptor activity
G-protein coupled receptor activity
protein binding
G-protein coupled peptide receptor activity
corticotrophin-releasing factor receptor activity
corticotropin-releasing hormone receptor activity
corticotropin-releasing hormone binding
G-protein alpha-subunit binding
peptide binding
macromolecular complex binding
peptide hormone binding
response to hypoxia
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
memory
feeding behavior
visual learning
hormone-mediated signaling pathway
adrenal gland development
adult behavior
epithelial cell differentiation
positive regulation of synaptic transmission, GABAergic
negative regulation of epinephrine secretion
multicellular organismal response to stress
exploration behavior
locomotory exploration behavior
fear response
positive regulation of mast cell degranulation
negative regulation of neuron apoptotic process
behavioral response to cocaine
behavioral response to ethanol
regulation of synaptic plasticity
behavioral response to pain
regulation of transport
positive regulation of corticotropin secretion
response to electrical stimulus
general adaptation syndrome
general adaptation syndrome, behavioral process
long-term synaptic potentiation
cellular response to corticotropin-releasing hormone stimulus
positive regulation of cAMP/PKA signal transduction
negative regulation of feeding behavior
regulation of corticosterone secretion
immune response
activation of adenylate cyclase activity
female pregnancy
parturition
cellular response to hormone stimulus
negative regulation of voltage-gated calcium channel activity
hypothalamus development
response to immobilization stress
positive regulation of secretion by cell
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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