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Invitrogen
BATF Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-34463
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 16 amino acid synthetic peptide near the amino terminus of human BATF
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is rat spleen tissue lysate.
PA5-34463 can be used with blocking peptide PEP-1505.
Target Information
BATF is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events and blocks cellular transformation by Ras and Fos. BATF also is required for the differentiation of IL-17-producing T helper (TH17) cells, a CD4+ subset of T cells that coordinates the inflammatory response in host defense. In both T cells and B cells, BATF is required for the appropriate regulation of the class-switch recombination.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activating transcription factor B; B-ATF; B-cell activating transcription factor; B-cell-activating transcription factor; basic leucine zipper transcription factor-like; Basic leucine zipper transcriptional factor ATF-like; SF-HT-activated gene 2 protein; SFA-2
Gene Aliases: B-ATF; BATF; SFA-2
UniProt ID: (Rat) D4A7E1, (Mouse) O35284
Entrez Gene ID: (Rat) 299206, (Mouse) 53314
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
molecular_function
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
DNA binding
protein binding
basic leucine zipper transcription factor
cytokine production
lymphoid progenitor cell differentiation
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
cellular response to DNA damage stimulus
biological_process
DNA damage response, signal transduction by p53 class mediator
defense response to protozoan
myeloid dendritic cell differentiation
T-helper 2 cell differentiation
isotype switching
positive regulation of transcription from RNA polymerase II promoter
hematopoietic stem cell differentiation
T-helper 17 cell differentiation
T-helper 17 cell lineage commitment
regulation of transcription, DNA-templated
cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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