Invitrogen

GFI1B Polyclonal Antibody

Name: GFI1B Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-35249
Availability: InStock

查看其他6个GFI1B抗体

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

Additional Information:

抗体检测数据 (1)

图: 1 / 1

GFI1B Antibody (PA5-35249) in WB

Western blot analysis of GFI1B in HL-60, K562, U266 cell line and mouse spleen lysates. Samples were incubated with GFI1B polyclonal antibody (Product # PA5-35249). Lysates: 35 µg/lane. GFI1B protein (arrow).

Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

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Immunogen Image GFI1B Polyclonal Antibody

产品信息

PA5-35249

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide between 302-330 amino acids from the C-terminal region of human GFI1B

3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

200 µg

纯化类型

Protein A, Antigen affinity chromatography

保存液

PBS, pH 7.4

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2552559

靶标信息

GFI1b (zinc finger protein GFI-1b) is an essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. It is also a component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. GFI1b also acts as a transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. It also cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Mutations affecting the gene are associated with Bleeding disorder, platelet-type 17 (BDPLT17).

仅用于科研。不用于诊断过程。未经明确授权不得转售。