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Invitrogen
Aurora B/C Polyclonal Antibody
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Aurora B/C Antibody (PA5-36126) in WB
Western blot analysis of Aurora B/C in Lane 1: HEK293T whole cell lysate (20 µg), Lane 2: HepG2 whole cell lysate (20 µg), Lane 3: PC3 whole cell lysate (40 µg), Lane 4: A549 whole cell lysate (40 µg), Lane 5: PC12 whole cell lysate (40 µg), Lane 6: AML-12 whole cell lysate (40 µg). Samples were incubated with Aurora B/C polyclonal antibody (Product # PA5-36126) at a dilution of 1:500.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-36126
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 163-213 of human AURKB
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody detects endogenous protein at a molecular weight of 35 and 39 kDa.
Purity is >95% by SDS-PAGE.
靶标信息
Aurora kinases belong to a highly conserved family of mitotic serine/threonine kinases with three members identified among mammals: Aurora A, B, and C. Studies on the temporal expression pattern and subcellular localization of Aurora kinases in mitotic cells suggest an association with mitotic structure. Aurora kinase functional influences span from G2 phase to cytokinesis and may be involved in key cell cycle events such as centrosome duplication, chromosome bi-orientation and segregation, cleavage furrow positioning, and ingression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AIM-1; ARK-2; ARK-3; Aurora 1; Aurora 3; aurora B; Aurora kinase B; Aurora kinase C; Aurora- and IPL1-like midbody-associated protein 1; aurora-B; aurora-related kinase 2; aurora-related kinase 3; Aurora/IPL1-related kinase 2; Aurora/IPL1-related kinase 3; Aurora/IPL1/Eg2 protein 1; serine/threonine kinase 12; serine/threonine kinase 13 (aurora/IPL-like); serine/threonine kinase 5; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 13; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase aurora-B; Serine/threonine-protein kinase aurora-C; STK-1
基因别名: AIE1; Aik2; AIK3; AIM-1; Aim1; AIRK2; Airk3; AL022959; ARK-2; ARK-3; Ark2; Ark3; AurB; Aurkb; Aurkc; IAK3; IPL1; STK-1; Stk1; Stk12; Stk13; Stk5
UniProt ID: (Mouse) O70126, (Rat) O55099, (Mouse) O88445
Entrez Gene ID: (Mouse) 20877, (Rat) 114592, (Mouse) 20871, (Rat) 292554
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
histone serine kinase activity
metal ion binding
non-receptor serine/threonine protein kinase
negative regulation of transcription from RNA polymerase II promoter
negative regulation of B cell apoptotic process
protein phosphorylation
cell cycle
spindle organization
mitotic spindle organization
mitotic nuclear division
phosphorylation
spindle checkpoint
negative regulation of protein binding
regulation of cytokinesis
positive regulation of cytokinesis
protein localization to kinetochore
cellular response to UV
cleavage furrow formation
histone H3-S28 phosphorylation
mitotic spindle midzone assembly
cell division
aging
cell proliferation
abscission
negative regulation of cytokinesis
regulation of signal transduction
histone-serine phosphorylation
meiotic cell cycle
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
