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Invitrogen
SCN4B Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-37419
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant full length human SCN4B
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody detects endogenous protein at a molecular weight of 37 kDa.
Purity is >95% by SDS-PAGE.
靶标信息
The SCN4B protein modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. The protein has been found to be expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10) [MIM:611819]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: sodium channel accessory subunit; sodium channel beta 4 subunit; Sodium channel regulatory subunit beta-4; sodium channel subunit beta-4; sodium channel, type IV, beta polypeptide; voltage gated sodium channel beta 4 subunit
基因别名: Gm1471; Scn4b
UniProt ID: (Mouse) Q7M729
Entrez Gene ID: (Mouse) 399548
transport
ion transport
sodium ion transport
positive regulation of sodium ion transport
regulation of ion transmembrane transport
sodium ion transmembrane transport
cardiac muscle contraction
regulation of ventricular cardiac muscle cell membrane repolarization
cardiac muscle cell action potential involved in contraction
membrane depolarization during cardiac muscle cell action potential
AV node cell action potential
regulation of heart rate by cardiac conduction
regulation of sodium ion transmembrane transporter activity
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
